In: Cancer Immunology, Immunotherapy, 2015, vol. 64, no. 8, p. 1033-1046
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In: Seminars in Immunopathology, 2015, vol. 37, no. 5, p. 519-528
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In: Integrative Biology, 2018, vol. 10, no. 9, p. 527-538
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In: Journal of Investigative Dermatology, 2020, vol. 140, no. 11, p. 2280-2290.e4
Chronic skin wounds accompany many prevalent age-related diseases and are a major cause of morbidity and mortality. Both keratinocytes and fibroblasts contribute to the pathomechanisms in chronic skin wounds. Dysregulated pathways in the epidermis have been extensively studied, but little is known of the influence of dermal fibroblasts on chronic wounding. We isolated fibroblasts from chronic...
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In: Cancers, 2019, vol. 11, no. 10, p. 1461
Breast cancer is the first cause of cancer-related mortality among women worldwide, according to the most recent estimates. This mortality is mainly caused by the tumors’ ability to form metastases. Cancer cell migration and invasion are essential for metastasis and rely on the interplay between actin cytoskeleton remodeling and cell adhesion. Therefore, understanding the mechanisms by which...
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In: Cancers, 2019, vol. 11, no. 7, p. 978
Correlative clinical evidence and experimental observations indicate that integrin adhesion receptors, in particular those of the αV family, are relevant to cancer cell features, including proliferation, survival, migration, invasion, and metastasis. In addition, integrins promote events in the tumor microenvironment that are critical for tumor progression and metastasis, including tumor...
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In: Plos one, 2011, vol. 6, no. 10, p. e26133
Mast cells have essential effector and immunoregulatory functions in IgE-associated allergic disorders and certain innate and adaptive immune responses, but the role of miRNAs in regulating mast cell functions is almost completely unexplored. To examine the role of the activation-induced miRNA miR-221 in mouse mast cells, we developed robust lentiviral systems for miRNA overexpression and...
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In: Biological Chemistry, 2015, vol. 396, no. 6-7, p. 813-825
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In: Seminars in Immunopathology, 2014, vol. 36, no. 2, p. 253-259
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In: Plos one, 2010, vol. 5, no. 4, p. e10159
Background: Migration of mammalian cells is a complex cell type and environment specific process. Migrating hematopoietic cells assume a rapid amoeboid like movement when exposed to gradients of chemoattractants. The underlying signaling mechanisms remain controversial with respect to localization and distribution of chemotactic receptors within the plasma membrane and the role of PI 3-kinase...
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