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A mindfulness-based program for improving quality of life among hematopoietic stem cell transplantation survivors: feasibility and preliminary findings

Grossman, Paul ; Zwahlen, Diana ; Halter, Jorg ; Passweg, Jakob ; Steiner, Claudia ; Kiss, Alexander

In: Supportive Care in Cancer, 2015, vol. 23, no. 4, p. 1105-1112

The role of hematopoietic stem cell transplantation in chronic myeloid leukemia

Gratwohl, Alois ; Baldomero, Helen ; Passweg, Jakob

In: Annals of Hematology, 2015, vol. 94, p. 177-186

Live Virus Vaccines in Transplantation: Friend or Foe?

Verolet, Charlotte ; Posfay-Barbe, Klara

In: Current Infectious Disease Reports, 2015, vol. 17, no. 4, p. 1-11

Synergistic effect of sorafenib and cGvHD in patients with high-risk FLT3-ITD+AML allows long-term disease control after allogeneic transplantation

Tschan-Plessl, A. ; Halter, J. ; Heim, D. ; Medinger, M. ; Passweg, J. ; Gerull, S.

In: Annals of Hematology, 2015, vol. 94, no. 11, p. 1899-1905

The role of TNFR2 and DR3 in the in vivo expansion of tregs in T cell depleting transplantation regimens

Rodriguez-Barbosa, Jose-Ignacio ; Schneider, Pascal ; Graca, Luis ; Bühler, Leo ; Perez-Simon, Jose-Antonio ; Rio, Maria-Luisa del

In: International Journal of Molecular Sciences, 2020, vol. 21, no. 9, p. 3347

Regulatory T cells (Tregs) are essential for the maintenance of tolerance to self and non-self through cell-intrinsic and cell-extrinsic mechanisms. Peripheral Tregs survival and clonal expansion largely depend on IL-2 and access to co-stimulatory signals such as CD28. Engagement of tumor necrosis factor receptor (TNFR) superfamily members, in particular TNFR2 and DR3, contribute to promote...

Highly significant antiviral activity of HIV-1 LTR-specific tre-recombinase in humanized mice

Hauber, Ilona ; Hofmann-Sieber, Helga ; Chemnitz, Jan ; Dubrau, Danilo ; Chusainow, Janet ; Stucka, Rolf ; Hartjen, Philip ; Schambach, Axel ; Ziegler, Patrick ; Hackmann, Karl ; Schröck, Evelin ; Schumacher, Udo ; Lindner, Christoph ; Grundhoff, Adam ; Baum, Christopher ; Manz, Markus G. ; Buchholz, Frank ; Hauber, Joachim

In: Plos pathogens, 2013, vol. 9, no. 9, p. e1003587

Stable integration of HIV proviral DNA into host cell chromosomes, a hallmark and essential feature of the retroviral life cycle, establishes the infection permanently. Current antiretroviral combination drug therapy cannot cure HIV infection. However, expressing an engineered HIV-1 long terminal repeat (LTR) site-specific recombinase (Tre), shown to excise integrated proviral DNA in vitro,...

Rag defects and thymic stroma : lessons from animal models

Marrella, Veronica ; Poliani, Pietro Luigi ; Notarangelo, Luigi Daniele ; Grassi, Fabio ; Villa, Anna

In: Frontiers in immunology, 2014, vol. 5, p. 259

Thymocytes and thymic epithelial cells (TECs) cross-talk is essential to support T cell development and preserve thymic architecture and maturation of TECs and Foxp3+ natural regulatory T cells. Accordingly, disruption of thymic lymphostromal cross-talk may have major implications on the thymic mechanisms that govern T cell tolerance. Several genetic defects have been described in humans that...

MicroRNAs in hematopoietic development

Montagner, Sara ; Dehó, Lorenzo ; Monticelli, Silvia

In: BMC immunology, 2014, vol. 15, p. 14

Background: MicroRNAs (miRNAs) are short non-coding RNAs involved in the posttranscriptional regulation of a wide range of biological processes. By binding to complementary sequences on target messenger RNAs, they trigger translational repression and degradation of the target, eventually resulting in reduced protein output. MiRNA-dependent regulation of protein translation is a very widespread...

Statin use and peripheral blood progenitor cells mobilization in patients with multiple myeloma

Stravodimou, A. ; Voutsadakis, I.

In: Clinical and Translational Oncology, 2014, vol. 16, no. 1, p. 85-90

Clinical usefulness of therapeutic concentration monitoring for imatinib dosage individualization: results from a randomized controlled trial

Gotta, V. ; Widmer, N. ; Decosterd, L. ; Chalandon, Y. ; Heim, D. ; Gregor, M. ; Benz, R. ; Leoncini-Franscini, L. ; Baerlocher, G. ; Duchosal, M. ; Csajka, C. ; Buclin, T.

In: Cancer Chemotherapy and Pharmacology, 2014, vol. 74, no. 6, p. 1307-1319