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Université de Fribourg

Seismic monitoring in the Gugla rock glacier (Switzerland): ambient noise correlation, microseismicity and modelling

Guillemot, Antoine ; Helmstetter, Agnès ; Larose, Éric ; Baillet, Laurent ; Garambois, Stéphane ; Mayoraz, Raphaël ; Delaloye, Reynald

In: Geophysical Journal International, 2020, vol. 221, no. 3, p. 1719–1735

A network of seismometers has been installed on the Gugla rock glacier since October 2015 to estimate seismic velocity changes and detect microseismicity. These two processes are related to mechanical and structural variations occurring within the rock glacier. Seismic monitoring thus allows a better understanding of the dynamics of rock glaciers throughout the year. We observed seasonal...

Università della Svizzera italiana

Insights into the effect of the G245S single point mutation on the structure of p53 and the binding of the protein to DNA

Lepre, Marco Gaetano ; Omar, Sara Ibrahim ; Grasso, Gianvito ; Morbiducci, Umberto ; Deriu, Marco Agostino ; Tuszynski, Jack A.

In: Molecules, 2017, vol. 22, no. 8, p. 1358

The transcription factor p53 is a potent tumor suppressor dubbed as the “guardian of the genome” because of its ability to orchestrate protective biological outputs in response to a variety of oncogenic stresses. Mutation and thus inactivation of p53 can be found in 50% of human tumors. The majority are missense mutations located in the DNA binding region. Among them, G245S is known to be...

Università della Svizzera italiana

Opening study on the development of a new biosensor for metal toxicity based on pseudomonas fluorescens pyoverdine

Chiadò, Alessandro ; Varani, Luca ; Bosco, Francesco ; Marmo, Luca

In: Biosensors, 2013, vol. 3, no. 4, p. 385-399

To date, different kinds of biosensing elements have been used effectively for environmental monitoring. Microbial cells seem to be well-suited for this task: they are cheap, adaptable to variable field conditions and give a measurable response to a broad number of chemicals. Among different pollutants, heavy metals are still a major problem for the environment. A reasonable starting point...