Affiner les résultats

Collection spécifique

Langue

Université de Fribourg

Disruption of gamma–delta relationship related to working memory deficits in first-episode psychosis

Missonnier, Pascal ; Prévot, Anne ; Herrmann, François R. ; Ventura, Joseph ; Padée, Anna ; Merlo, Marco C. G.

In: Journal of Neural Transmission, 2020, vol. 127, no. 1, p. 103–115

Working memory (WM) deficits constitute a core symptom of schizophrenia. Inadequacy of WM maintenance in schizophrenia has been reported to reflect abnormalities in the excitation/inhibition (E/I) balance between pyramidal neurons and parvalbumin basket cells, which may explain alterations of the dynamics of gamma and delta oscillations. To address this issue, we assessed event-related gamma...

Université de Fribourg

Striatal responsiveness to reward under threat‐of‐shock and working memory load : A preliminary study

Gaillard, Claudie ; Guillod, Matthias ; Ernst, Monique ; Torrisi, Salvatore ; Federspiel, Andrea ; Schoebi, Dominik ; Recabarren, Romina E. ; Ouyang, Xinyi ; Mueller-Pfeiffer, Christoph ; Horsch, Antje ; Homan, Philipp ; Wiest, Roland ; Hasler, Gregor ; Martin-Soelch, Chantal

In: Brain and Behavior, 2019, no. 9, p. 1-21

Introduction: Reward and stress are important determinants of motivated behaviors. Striatal regions play a crucial role in both motivation and hedonic processes. So far, little is known on how cognitive effort interacts with stress to modulate reward processes. This study examines how cognitive effort (load) interacts with an unpredictable acute stressor (threat-of-shock) to modulate motivational...

Université de Fribourg

Progressive signaling changes in the olfactory nerve of patients with Alzheimer’s disease

Bathini, Praveen ; Mottas, Antoine ; Jaquet, Muriel ; Brai, Emanuele ; Alberi, Lavinia

In: Neurobiology of Aging, 2019, vol. 76, p. 80–95

Olfaction declines with aging and appears to be a prodromal sign of cognitive decline in progressive neurodegenerative diseases. Nevertheless, very little is known about the pathophysiological changes underlying smell loss that may reflect early network dysfunction. A cross-sectional histoanatomical study was conducted on postmortem olfactory nerves of patients with increasing severity of...