In: Medizinische Klinik - Intensivmedizin und Notfallmedizin, 2015, vol. 110, no. 5, p. 338-345
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In: Intensive Care Medicine, 2015, vol. 41, no. 6, p. 1029-1036
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In: Pharmacological Research, 2019, vol. 145, p. 104263
Poly(ADP-ribose) polymerase (PARP) is involved in the pathogenesis of cell dysfunction, inflammation and organ failure during septic shock. The goal of the current study was to investigate the efficacy and safety of the clinically approved PARP inhibitor olaparib in experimental models of oxidative stress in vitro and in sepsis in vivo. In mice subjected to cecal ligation and puncture (CLP)...
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In: Clinical Chemistry and Laboratory Medicine (CCLM), 2015, vol. 53, no. 4, p. 583-592
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In: International Orthopaedics, 2014, vol. 38, no. 6, p. 1283-1290
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In: Intensive Care Medicine Experimental, 2018, vol. 6, no. 1, p. 43
Sepsis is associated with disturbed glucose metabolism and reduced mitochondrial activity and biogenesis, ultimately leading to multiple organ dysfunction, e.g., acute kidney injury (AKI). Cystathionine-γ-lyase (CSE), the major cardiovascular source of endogenous H2S release, is implicated in the regulation of glucose metabolism and mitochondrial activity through a PGC1α-dependent...
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In: Intensive Care Medicine, 2011, vol. 37, no. 9, p. 1432-1437
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In: Intensive Care Medicine, 2009, vol. 35, no. 7, p. 1225-1233
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