In: Neurochemical Research, 2015, vol. 40, no. 12, p. 2639-2646
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In: Diabetologia, 2015, vol. 58, no. 2, p. 221-232
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In: Cerebral Cortex, 2018, vol. 28, no. 1, p. 184-198
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In: Brain, 2016, vol. 139, no. 5, p. 1587-1604
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In: Surgical and radiologic anatomy, 2021, p. 13 p
The embryological development of the cerebral vasculature is very complex. Historical and also more recent studies based on human embryos, comparative anatomy and cerebral angiographies allowed us to better understand this vasculature development. The knowledge and understanding of such embryological development are important for physicians interested in neurovascular pathologies. Indeed, all...
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In: Cells, 2020, vol. 9, no. 7, p. 1695
The aged population is currently at its highest level in human history and is expected to increase further in the coming years. In humans, aging is accompanied by impaired angiogenesis, diminished blood flow and altered metabolism, among others. A cellular mechanism that impinges upon these manifestations of aging can be a suitable target for therapeutic intervention. Here we identify cell...
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In: Pathogens, 2020, vol. 9, no. 1, p. 21
Microglia are the chief immune cells of the brain and have been reported to be activated in severe malaria. Their activation may drive towards neuroinflammation in cerebral malaria. Malaria-infected red blood cell derived-extracellular vesicles (MiREVs) are produced during the blood stage of malaria infection. They mediate intercellular communication and immune regulation, among other...
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In: Brain Sciences, 2020, vol. 10, no. 1, p. 31
Cerebral microvascular endothelial cells (CMVECs) line the vascular system of the brain and are the chief cells in the formation and function of the blood brain barrier (BBB). These cells are heterogeneous along the cerebral vasculature and any dysfunctional state in these cells can result in a local loss of function of the BBB in any region of the brain. There is currently no report on the...
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In: Frontiers in immunology, 2019, vol. 10, p. 711
Breakdown of the blood-brain barrier (BBB) and increased immune cell trafficking into the central nervous system (CNS) are hallmarks of the pathogenesis of multiple sclerosis (MS). Platelet endothelial cell adhesion molecule-1 (PECAM-1; CD31) is expressed on cells of the vascular compartment and regulates vascular integrity and immune cell trafficking. Involvement of PECAM-1 in MS pathogenesis...
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In: Acta Neurochirurgica, 2014, vol. 156, no. 11, p. 2095-2101
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