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Université de Fribourg

CD47 promotes age-associated deterioration in angiogenesis, blood flow and glucose homeostasis

Ghimire, Kedar ; Li, Yao ; Chiba, Takuto ; Julovi, Sohel M. ; Li, Jennifer ; Ross, Mark A. ; Straub, Adam C. ; O’Connell, Philip J. ; Rüegg, Curzio ; Pagano, Patrick J. ; Isenberg, Jeffrey S. ; Rogers, Natasha M.

In: Cells, 2020, vol. 9, no. 7, p. 1695

The aged population is currently at its highest level in human history and is expected to increase further in the coming years. In humans, aging is accompanied by impaired angiogenesis, diminished blood flow and altered metabolism, among others. A cellular mechanism that impinges upon these manifestations of aging can be a suitable target for therapeutic intervention. Here we identify cell...

Université de Fribourg

Effects of continuous theta burst stimulation over the left DLPFC on mother tongue and second language production in late bilinguals: a behavioral and ERP study

Jost, Lea B. ; Pestalozzi, Maria I. ; Cazzoli, Dario ; Mouthon, Michael ; Müri, René M. ; Annoni, Jean‑Marie

In: Brain Topography, 2020, vol. 33, no. 4, p. 504–518

Clinical, neuroimaging, and non-invasive brain stimulation studies have associated the dorsolateral prefrontal cortex (DLPFC) with the multilingual language control system. Here, we investigated if this role is increased during the processing of the non- dominant language due to the higher cognitive/attentional demands. We used an inhibitory repetitive transcranial magnetic stimulation (rTMS)...

Université de Fribourg

Effects of theta burst stimulation over the dorsolateral prefrontal cortex on language switching – A behavioral and ERP study

Pestalozzi, Maria I. ; Annoni, Jean-Marie ; Müri, René M. ; Jost, Lea B.

In: Brain and Language, 2020, vol. 205, p. 104775

This study investigated the role of the left dorsolateral prefrontal cortex (DLPFC) in language switching using theta burst stimulation (TBS) and electroencephalography in late bilinguals. After a sham-controlled baseline, participants received either excitatory or inhibitory TBS over the left DLPFC before conducting picture naming tasks in pure language blocks and a language switching...

Université de Fribourg

Assessment of the effect of continuous theta burst stimulation of the motor cortex on manual dexterity in non-human primates in a direct comparison with invasive intracortical pharmacological inactivation

Roux, Camille ; Kaeser, Mélanie ; Savidan, Julie ; Fregosi, Michela ; Rouiller, Eric M. ; Schmidlin, Eric

In: European Journal of Neuroscience, 2019, p. -

Non-invasive reversible perturbation techniques of brain output such as continuous theta burst stimulation (cTBS), commonly used to modulate cortical excitability in humans, allow investigation of possible roles in functional recovery played by distinct intact cortical areas following stroke. To evaluate the potential of cTBS, the behavioural effects of this non-invasive transient...

Université de Fribourg

Dorsolateral prefrontal transcranial direct current stimulation modulates language processing but does not facilitate overt second language word production

Radman, Narges ; Britz, Juliane ; Buetler, Karin ; Weekes, Brendan S. ; Spierer, Lucas ; Annoni, Jean-Marie

In: Frontiers in Neuroscience, 2018, vol. 12, p. -

Word retrieval in bilingual speakers partly depends on executive-control systems in the left prefrontal cortex - including dorsolateral prefrontal cortex (DLPFC). We tested the hypothesis that DLPFC modulates word production of words specifically in a second language (L2) by measuring the effects of anodal transcranial direct current stimulation (anodal-tDCS) over the DLPFC on picture naming...