In: Human Reproduction, 2017, vol. 32, no. 4, p. 820-831
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In: Inflammation Research, 2015, vol. 64, no. 7, p. 527-536
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In: Journal of Molecular Cell Biology, 2016, vol. 8, no. 1, p. 62-72
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In: Glycobiology, 2018, vol. 28, no. 9, p. 640-647
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In: Cancer Immunology, Immunotherapy, 2015, vol. 64, no. 5, p. 635-644
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In: Psychopharmacology, 2015, vol. 232, no. 16, p. 2981-2994
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In: SLEEP, 2016, vol. 40, no. 3, p. -
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In: Cell, 2016, vol. 166, no. 3, p. 596-608
Influenza virus remains a threat because of its ability to evade vaccine-induced immune responses due to antigenic drift. Here, we describe the isolation, evolution, and structure of a broad-spectrum human monoclonal antibody (mAb), MEDI8852, effectively reacting with all influenza A hemagglutinin (HA) subtypes. MEDI8852 uses the heavy-chain VH6-1 gene and has higher potency and breadth when...
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In: Annual Review of Immunology
P. falciparum remains a serious public health problem and a continuous challenge for the immune system due to the complexity and diversity of the pathogen. Recent advances from several laboratories in the characterization of the antibody response to the parasite have led to the identification of critical targets for protection and revealed a new mechanism of diversification based on the...
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In: Current opinion in immunology, 2016, vol. 41, no. August, p. 62-67
In the last decade, progress in the analysis of the human immune response and in the isolation of human monoclonal antibodies have provided an innovative approach to the identification of protective antigens which are the basis for the design of vaccines capable of eliciting effective B-cell immunity. In this review we illustrate, with relevant examples, the power of this approach that can...
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