Università della Svizzera italiana

The antibody response to Plasmodium falciparum : cues for vaccine design and the discovery of receptor-based antibodies

Tan, Joshua ; Piccoli, Luca ; Lanzavecchia, Antonio

In: Annual Review of Immunology

P. falciparum remains a serious public health problem and a continuous challenge for the immune system due to the complexity and diversity of the pathogen. Recent advances from several laboratories in the characterization of the antibody response to the parasite have led to the identification of critical targets for protection and revealed a new mechanism of diversification based on the...

Université de Fribourg

γδ T cells kill Plasmodium falciparum in a granzyme- and granulysin-dependent mechanism during the late blood stage

Hernández-Castañeda, Maria Andrea ; Happ, Katharina ; Cattalani, Filippo ; Wallimann, Alexandra ; Blanchard, Marianne ; Fellay, Isabelle ; Scolari, Brigitte ; Lannes, Nils ; Mbagwu, Smart Ikechukwu ; Fellay, Benoît ; Filgueira, Luis ; Mantel, Pierre-Yves ; Walch, Michael

In: The Journal of Immunology, 2020, vol. 204, no. 7, p. 1798–1809

Plasmodium spp., the causative agent of malaria, have a complex life cycle. The exponential growth of the parasites during the blood stage is responsible for almost all malaria-associated morbidity and mortality. Therefore, tight immune control of the intraerythrocytic replication of the parasite is essential to prevent clinical malaria. Despite evidence that the particular lymphocyte subset ...

Université de Fribourg

Evaluation of extracellular vesicle function during malaria infection

Andrea Hernández-Castañeda, María ; Mbagwu, Smart Ikechukwu ; Babatunde, Kehinde Adebayo ; Walch, Michael ; Filgueira, Luis ; Mantel, Pierre-Yves

In: JoVE (Journal of Visualized Experiments), 2018, no. 132, p. e57067

Malaria is a life-threatening disease caused by Plasmodium parasites, with P. falciparum being the most prevalent on the African continent and responsible for most malaria-related deaths globally. Several factors including parasite sequestration in tissues, vascular dysfunction, and inflammatory responses influence the evolution of the disease in malaria-infected people. P. falciparum-infected...

Consortium of Swiss Academic Libraries

Characterization of Stapes Anatomy: Investigation of Human and Guinea Pig

Sim, Jae ; Röösli, Christof ; Chatzimichalis, Michail ; Eiber, Albrecht ; Huber, Alexander

In: Journal of the Association for Research in Otolaryngology, 2013, vol. 14, no. 2, p. 159-173