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U.S. vaccine and immune globulin product shortages, 2001-15

Ziesenitz, Victoria C. ; Mazer-Amirshahi, Maryann ; Zocchi, Mark S. ; Fox, Erin R. ; May, Larissa S.

In: American Journal of Health-System Pharmacy, 2017, vol. 74, no. 22, p. 1879-1886

Preventive chemotherapy to control soil-transmitted helminthiasis averted more than 500 000 DALYs in 2015

Montresor, A. ; Trouleau, W. ; Mupfasoni, D. ; Bangert, M. ; Joseph, S A. ; Mikhailov, A. ; Fitzpatrick, C.

In: Transactions of The Royal Society of Tropical Medicine and Hygiene, 2017, vol. 111, no. 10, p. 457-463

Single-Dose Hepatitis A Immunization: 7.5-Year Observational Pilot Study in Nicaraguan Children to Assess Protective Effectiveness and Humoral Immune Memory Response

Mayorga, Orlando ; Bühler, Silja ; Jaeger, Veronika K. ; Bally, Seraina ; Hatz, Christoph ; Frösner, Gert ; Protzer, Ulrike ; Van Damme, Pierre ; Egger, Matthias ; Herzog, Christian

In: The Journal of Infectious Diseases, 2016, vol. 214, no. 10, p. 1498-1506

Structure and function analysis of an antibody recognizing all influenza A subtypes

Kallewaard, Nicole L. ; Corti, Davide ; Collins, Patrick J. ; Neu, Ursula ; McAuliffe, Josephine M. ; Benjamin, Ebony ; Wachter-Rosati, Leslie ; Palmer-Hill, Frances J. ; Yuan, Andy Q. ; Walker, Philip A. ; Vorlaender, Matthias K. ; Bianchi, Siro ; Guarino, Barbara ; De Marco, Anna ; Vanzetta, Fabrizia ; Agatic, Gloria ; Foglierini, Mathilde ; Pinna, Debora ; Fernandez-Rodriguez, Blanca ; Fruehwirth, Alexander ; Silacci, Chiara ; Ogrodowicz, Roksana W. ; Martin, Stephen R. ; Sallusto, Federica ; Suzich, JoAnn A. ; Lanzavecchia, Antonio ; Zhu, Qing ; Gamblin, Steven J. ; Skehel, John J.

In: Cell, 2016, vol. 166, no. 3, p. 596-608

Influenza virus remains a threat because of its ability to evade vaccine-induced immune responses due to antigenic drift. Here, we describe the isolation, evolution, and structure of a broad-spectrum human monoclonal antibody (mAb), MEDI8852, effectively reacting with all influenza A hemagglutinin (HA) subtypes. MEDI8852 uses the heavy-chain VH6-1 gene and has higher potency and breadth when...

Antibody-guided vaccine design : identification of protective epitopes

Lanzavecchia, Antonio ; Frühwirth, Alexander ; Perez, Laurent ; Corti, Davide

In: Current opinion in immunology, 2016, vol. 41, no. August, p. 62-67

In the last decade, progress in the analysis of the human immune response and in the isolation of human monoclonal antibodies have provided an innovative approach to the identification of protective antigens which are the basis for the design of vaccines capable of eliciting effective B-cell immunity. In this review we illustrate, with relevant examples, the power of this approach that can...

Molecular signatures of immunity and immunogenicity in infection and vaccination

Haks, Mariëlle C. ; Bottazzi, Barbara ; Cecchinato, Valentina ; De Gregorio, Corinne ; Del Giudice, Giuseppe ; Kaufmann, Stefan H. E. ; Lanzavecchia, Antonio ; Lewis, David J. M. ; Maertzdorf, Jeroen ; Mantovani, Alberto ; Sallusto, Federica ; Sironi, Marina ; Uguccioni, Mariagrazia ; Ottenhoff, Tom H. M.

In: Frontiers in immunology, 2017, vol. 8, p. 1563

Vaccinology aims to understand what factors drive vaccine-induced immunity and protection. For many vaccines, however, the mechanisms underlying immunity and protection remain incompletely characterized at best, and except for neutralizing antibodies induced by viral vaccines, few correlates of protection exist. Recent omics and systems biology big data platforms have yielded valuable...

Changing Face of Vaccination in Immunocompromised Hosts

O'Shea, Daire ; Widmer, Lukas ; Stelling, Jörg ; Egli, Adrian

In: Current Infectious Disease Reports, 2014, vol. 16, no. 9, p. 1-11

Factors that influence the immune response to vaccination

Zimmermann, Petra ; Curtis, Nigel

In: Clinical Microbiology Reviews, 2019, vol. 32, no. 2, p. e00084-18

There is substantial variation between individuals in the immune response to vaccination. In this review, we provide an overview of the plethora of studies that have investigated factors that influence humoral and cellular vaccine responses in humans. These include intrinsic host factors (such as age, sex, genetics, and comorbidities), perinatal factors (such as gestational age, birth weight,...

Harmonization guidelines for HLA-peptide multimer assays derived from results of a large scale international proficiency panel of the Cancer Vaccine Consortium

Britten, Cedrik ; Janetzki, Sylvia ; Ben-Porat, Leah ; Clay, Timothy ; Kalos, Michael ; Maecker, Holden ; Odunsi, Kunle ; Pride, Michael ; Old, Lloyd ; Hoos, Axel ; Romero, Pedro

In: Cancer Immunology, Immunotherapy, 2009, vol. 58, no. 10, p. 1701-1713

Detection and treatment of HIV and hepatitis virus infections in Swiss correctional facilities

Gerlich, Miriam ; Frick, Ulrich ; Pirktl, Lynn ; Uchtenhagen, Ambros

In: International Journal of Public Health, 2008, vol. 53, no. 5, p. 268-271