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Université de Fribourg

Identification of avoidance genes through neural pathway-specific forward optogenetics

Marques, Filipe ; Saro, Gabriella ; Lia, Andrei-Stefan ; Poole, Richard J. ; Falquet, Laurent ; Glauser, Dominique A.

In: PLOS Genetics, 2019, vol. 15, no. 12, p. e1008509

Understanding how the nervous system bridges sensation and behavior requires the elucidation of complex neural and molecular networks. Forward genetic approaches, such as screens conducted in C. elegans, have successfully identified genes required to process natural sensory stimuli. However, functional redundancy within the underlying neural circuits, which are often organized with multiple...

Université de Fribourg

Reward-related suppression of neural activity in macaque visual area v4

Shapcott, Katharine A ; Schmiedt, Joscha T ; Kouroupaki, Kleopatra ; Kienitz, Ricardo ; Lazar, Andreea ; Singer, Wolf ; Schmid, Michael C

In: Cerebral Cortex, 2020, vol. 30, no. 9, p. 4871–4881

In order for organisms to survive, they need to detect rewarding stimuli, for example, food or a mate, in a complex environment with many competing stimuli. These rewarding stimuli should be detected even if they are nonsalient or irrelevant to the current goal. The value-driven theory of attentional selection proposes that this detection takes place through reward-associated stimuli...

Université de Fribourg

V1-bypassing thalamo-cortical visual circuits in blindsight and developmental dyslexia

Rima, Samy ; Schmid, Michael Christoph

In: Current Opinion in Physiology, 2020, vol. 16, p. 14–20

Vision rests on computations that primarily rely on the parvocellular and magnocellular geniculate relay of retinal signals to V1. Secondary pathways involving superior colliculus, koniocellular lateral geniculate nucleus and pulvinar and their V1-bypassing projections to higher order cortex are known to exist. While they may form an evolutionary old visual system, their contribution to...

Université de Fribourg

Role of the thalamus in basal forebrain regulation of neural activity in the primary auditory cortex

Azimi, Hamid ; Klaassen, Arndt-Lukas ; Thomas, Kevin ; Harvey, Michael A. ; Rainer, Gregor

In: Cerebral Cortex, 2020, vol. 30, no. 8, p. 4481–4495

Many studies have implicated the basal forebrain (BF) as a potent regulator of sensory encoding even at the earliest stages of or cortical processing. The source of this regulation involves the well-documented corticopetal cholinergic projections from BF to primary cortical areas. However, the BF also projects to subcortical structures, including the thalamic reticular nucleus (TRN), which...

Université de Fribourg

The Dynamic Reorganization of Cortical Network Interactions during Visual Selective Attention

Pagnotta, Mattia ; Plomp, Gijs (Dir.)

Thèse de doctorat : Université de Fribourg, 2020.

Visual selective attention prioritizes the processing of behaviorally relevant over irrelevant information, to optimize the use of limited cognitive resources in the brain. These selective mechanisms preferentially route relevant neuronal representations through a network of distributed brain regions. Previous studies suggested that selective information routing in the attention network may...