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Targeting the DNA damage response for patients with lymphoma : preclinical and clinical evidences

Carrassa, Laura ; Colombo, Ilaria ; Damia, Giovanna ; Bertoni, Francesco

In: Cancer treatment reviews, 2020, vol. 90, p. 11

The DNA damage response (DDR) is a well-coordinated cellular network activated by DNA damage. The unravelling of the key players in DDR, their specific inactivation in different tumor types and the synthesis of specific chemical inhibitors of DDR represent a new hot topic in cancer therapy. In this article, we will review the importance of DDR in lymphoma development and how this can be...

Pyriform sinus squamous cell carcinoma: oncological outcomes in good responders of induction chemotherapy-based larynx preservation protocols

Vourexakis, Zacharias ; Le Ridant, Anne-Marie ; Dulguerov, Pavel ; Janot, François

In: European Archives of Oto-Rhino-Laryngology, 2015, vol. 272, no. 7, p. 1725-1731

Oral lichen planus (OLP), oral lichenoid lesions (OLL), oral dysplasia, and oral cancer: retrospective analysis of clinicopathological data from 2002-2011

Casparis, S. ; Borm, J. ; Tektas, S. ; Kamarachev, J. ; Locher, M. ; Damerau, G. ; Grätz, K. ; Stadlinger, B.

In: Oral and Maxillofacial Surgery, 2015, vol. 19, no. 2, p. 149-156

Retinoic acid sensitivity of triple-negative breast cancer cells characterized by constitutive activation of the NOTCH1 pathway : the role of RARβ

Paroni, Gabriela ; Zanetti, Adriana ; Barzago, Maria Monica ; Kurosaki, Mami ; Guarrera, Luca ; Fratelli, Maddalena ; Troiani, Martina ; Ubezio, Paolo ; Bolis, Marco ; Vallerga, Arianna ; Biancardi, Federica ; Terao, Mineko ; Garattini, Enrico

In: Cancers, 2020, vol. 12, no. 10, p. 23 p

Triple-negative breast cancer (TNBC) is a heterogeneous disease that lacks effective therapeutic options. In this study, we profile eighteen TNBC cell lines for their sensitivity to the anti-proliferative action of all-trans retinoic acid (ATRA). The only three cell lines (HCC-1599, MB- 157 and MDA-MB-157) endowed with ATRA-sensitivity are characterized by genetic aberrations of the NOTCH1-gene,...

Impact of Preoperative Risk Factors on Morbidity after Esophagectomy: Is There Room for Improvement?

Mantziari, Styliani ; Hübner, Martin ; Demartines, Nicolas ; Schäfer, Markus

In: World Journal of Surgery, 2014, vol. 38, no. 11, p. 2882-2890

FDG PET and PET/CT for the detection of the primary tumour in patients with cervical non-squamous cell carcinoma metastasis of an unknown primary

Paul, Stefan ; Stoeckli, Sandro ; von Schulthess, Gustav ; Goerres, Gerhard

In: European Archives of Oto-Rhino-Laryngology, 2007, vol. 264, no. 2, p. 189-195

Second primary squamous cell carcinoma arising in cutaneous flap reconstructions of two head and neck cancer patients

Monnier, Yan ; Pasche, Philippe ; Monnier, Philippe ; Andrejevic-Blant, Snezana

In: European Archives of Oto-Rhino-Laryngology, 2008, vol. 265, no. 7, p. 831-835

p53 mutation in histologically normal mucosa of the aero-digestive tract is not a marker of increased risk for second primary carcinoma in head and neck cancer patients

Escher, Anette ; Piotet, Elsa ; Waridel, Francois ; Iggo, Richard ; Monnier, Philippe

In: European Archives of Oto-Rhino-Laryngology, 2009, vol. 266, no. 4, p. 547-551

Differentiated dysplasia is a frequent precursor or associated lesion in invasive squamous cell carcinoma of the oral cavity and pharynx

Arsenic, Ruza ; Kurrer, Michael

In: Virchows Archiv, 2013, vol. 462, no. 6, p. 609-617

Head and neck squamous cell carcinoma (HNSCC) - detection of synchronous primaries with 18F-FDG-PET/CT

Strobel, Klaus ; Haerle, Stephan ; Stoeckli, Sandro ; Schrank, Madeleine ; Soyka, Jan ; Veit-Haibach, Patrick ; Hany, Thomas

In: European Journal of Nuclear Medicine and Molecular Imaging, 2009, vol. 36, no. 6, p. 919-927