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IL-1 Antagonism in Men With Metabolic Syndrome and Low Testosterone: A Randomized Clinical Trial

Ebrahimi, Fahim ; Urwyler, Sandrine A. ; Straumann, Sven ; Doerpfeld, Simone ; Bernasconi, Luca ; Neyer, Peter ; Schuetz, Philipp ; Mueller, Beat ; Donath, Marc Y. ; Christ-Crain, Mirjam

In: The Journal of Clinical Endocrinology & Metabolism, 2018, vol. 103, no. 9, p. 3466-3476

N -methyl pyrrolidone (NMP) inhibits lipopolysaccharide-induced inflammation by suppressing NF-κB signaling

Ghayor, Chafik ; Gjoksi, Bebeka ; Siegenthaler, Barbara ; Weber, Franz

In: Inflammation Research, 2015, vol. 64, no. 7, p. 527-536

Associations of Serum 25-Hydroxyvitamin D With Hemostatic and Inflammatory Biomarkers in the Multi-Ethnic Study of Atherosclerosis

Blondon, Marc ; Cushman, Mary ; Jenny, Nancy ; Michos, Erin D. ; Smith, Nicholas L. ; Kestenbaum, Bryan ; de Boer, Ian H.

In: The Journal of Clinical Endocrinology & Metabolism, 2016, vol. 101, no. 6, p. 2348-2357

Ex vivo differential phase contrast and magnetic resonance imaging for characterization of human carotid atherosclerotic plaques

Meletta, Romana ; Borel, Nicole ; Stolzmann, Paul ; Astolfo, Alberto ; Klohs, Jan ; Stampanoni, Marco ; Rudin, Markus ; Schibli, Roger ; Krämer, Stefanie ; Müller Herde, Adrienne

In: The International Journal of Cardiovascular Imaging, 2015, vol. 31, no. 7, p. 1425-1434

Impact of Thyroid Hormone Therapy on Atherosclerosis in the Elderly With Subclinical Hypothyroidism: A Randomized Trial

Blum, Manuel R. ; Gencer, Baris ; Adam, Luise ; Feller, Martin ; Collet, Tinh-Hai ; da Costa, Bruno R. ; Moutzouri, Elisavet ; Dopheide, Jörn ; Depairon, Michèle ; Sykiotis, Gerasimos P. ; Kearney, Patricia ; Gussekloo, Jacobijn ; Westendorp, Rudi ; Stott, David J. ; Bauer, Douglas C. ; Rodondi, Nicolas

In: The Journal of Clinical Endocrinology & Metabolism, 2018, vol. 103, no. 8, p. 2988-2997

Serum cholesterol acceptor capacity in intrauterine growth restricted fetuses

Pecks, Ulrich ; Rath, Werner ; Bauerschlag, Dirk O. ; Maass, Nicolai ; Orlikowsky, Thorsten ; Mohaupt, Markus G. ; Escher, Geneviève

In: Journal of Perinatal Medicine, 2017, vol. 45, no. 7, p. 829-835

An inflamed human alveolar model for testing the efficiency of anti-inflammatory drugs in vitro

Drasler, Barbara ; Karakocak, Bedia Begum ; Tankus, Esma Bahar ; Barosova, Hana ; Abe, Jun ; Sousa de Almeida, Mauro ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Frontiers in Bioengineering and Biotechnology, 2020, vol. 8, p. -

A large number of prevalent lung diseases is associated with tissue inflammation. Clinically, corticosteroid therapies are applied systemically or via inhalation for the treatment of lung inflammation, and a number of novel therapies are being developed that require preclinical testing. In alveoli, macrophages and dendritic cells play a key role in initiating and diminishing pro-inflammatory...

Innate immune cells and their contribution to T-cell-based immunotherapy

Ginefra, Pierpaolo ; Lorusso, Girieca ; Vannini, Nicola

In: International Journal of Molecular Sciences, 2020, vol. 21, no. 12, p. 4441

In recent years, immunotherapy has become the most promising therapy for a variety of cancer types. The development of immune checkpoint blockade (ICB) therapies, the adoptive transfer of tumor-specific T cells (adoptive cell therapy (ACT)) or the generation of T cells engineered with chimeric antigen receptors (CAR) have been successfully applied to elicit durable immunological responses in...

Alimentation et maladies auto-immunes : existe-t-il des nutriments dont les effets sur la modulation de l'inflammation ou l'immunité auraient été démontrés sur plusieurs maladies auto-immunes différentes ? : travail de Bachelor

Grimm, Djamila ; Parel, Nicolas

Mémoire de bachelor : Haute école de santé Genève, 2019.

Introduction : L’altération de la capacité du système immunitaire à reconnaître le soi du non soi entraîne une réaction auto immune. Les maladies auto immunes sont des pathologies inflammatoires chroniques. Elles détériorent profondément la qualité de vie des personnes qui en sont atteintes. Il n’existe actuellement aucun traitement curatif pour ces pathologies. Les effets...

Are integrins still practicable targets for anti-cancer therapy?

Alday-Parejo, Begoña ; Stupp, Roger ; Rüegg, Curzio

In: Cancers, 2019, vol. 11, no. 7, p. 978

Correlative clinical evidence and experimental observations indicate that integrin adhesion receptors, in particular those of the αV family, are relevant to cancer cell features, including proliferation, survival, migration, invasion, and metastasis. In addition, integrins promote events in the tumor microenvironment that are critical for tumor progression and metastasis, including tumor...