Consortium of Swiss Academic Libraries

The Role of Humoral Mediators in Migraine Headache

Fanchamps, A.

In: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1974, vol. 1, no. 3, p. 189-195

Université de Fribourg

A Combination of screening and computational approaches for the identification of novel compounds that decrease mast cell degranulation

McShane, Marisa P. ; Friedrichson, Tim ; Giner, Angelika ; Meyenhofer, Felix ; Barsacchi, Rico ; Bickle, Marc ; Zerial, Marino

In: Journal of Biomolecular Screening, 2015, p. 1087057115579613

High-content screening of compound libraries poses various challenges in the early steps in drug discovery such as gaining insights into the mode of action of the selected compounds. Here, we addressed these challenges by integrating two biological screens through bioinformatics and computational analysis. We screened a small-molecule library enriched in amphiphilic compounds in a degranulation...

Université de Fribourg

Effect of chronic renal failure on the hepatic, intestinal, and renal expression of bile acid transporters

Gai, Zhibo ; Chu, Lei ; Hiller, Christian ; Arsenijevic, Denis ; Penno, Carlos A. ; Montani, Jean-Pierre ; Odermatt, Alex ; Kullak-Ublic, Gerd A.

In: American Journal of Physiology - Renal Physiology, 2014, vol. 306, no. 1, p. F130–F137

Although the kidney is believed to play a minor role in bile acid (BA) excretion, chronic renal failure (CRF) has been reported to be associated with increased serum bile acid levels and alterations in BA homeostasis. The mechanisms for elevated BA levels are poorly understood in both clinical and experimental studies. This study was designed to examine the effects of naturally progressing CRF of...

Université de Fribourg

Mast cells and macrophages in duodenal mucosa of mice overexpressing erythropoietin

Ribatti, Domenico ; Crivellato, Enrico ; Nico, Beatrice ; Guidolin, Diego ; Gassmann, Max ; Djonov, Valentin

In: Journal of Anatomy, 2009///doi: 10.1111/j.1469-7580.2009.01131.x

There is increasing evidence suggesting a wider biological role of erythropoietin (Epo) and Epo receptor (EpoR) not related to erythropoiesis, such as the detection of EpoR in other cells, i.e. polymorphonuclear leukocytes, megakaryocytes, endothelial, myocardial and neural cells. In this study, by using a mouse model (designated tg6) that constitutively overexpresses human Epo in an...