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Saving Human Lives: What Complexity Science and Information Systems can Contribute

Helbing, Dirk ; Brockmann, Dirk ; Chadefaux, Thomas ; Donnay, Karsten ; Blanke, Ulf ; Woolley-Meza, Olivia ; Moussaid, Mehdi ; Johansson, Anders ; Krause, Jens ; Schutte, Sebastian ; Perc, Matjaž

In: Journal of Statistical Physics, 2015, vol. 158, no. 3, p. 735-781

Increased risk of joint failure in hip prostheses infected with Staphylococcus aureus treated with debridement, antibiotics and implant retention compared to Streptococcus

Betz, Michael ; Abrassart, Sophie ; Vaudaux, Pierre ; Gjika, Ergys ; Schindler, Maximilian ; Billières, Julien ; Zenelaj, Besa ; Suvà, Domizio ; Peter, Robin ; Uçkay, Ilker

In: International Orthopaedics, 2015, vol. 39, no. 3, p. 397-401

Impact of round-the-clock CSF Gram stain on empirical therapy for suspected central nervous system infections

Tissot, F. ; Prod'hom, G. ; Manuel, O. ; Greub, G.

In: European Journal of Clinical Microbiology & Infectious Diseases, 2015, vol. 34, no. 9, p. 1849-1857

Fast and reliable detection of carbapenemase genes in various Gram negatives using a new commercially available fluorescence-based real-time polymerase chain reaction platform

Sadek, Mustafa ; Demord, Anthony ; Poirel, Laurent ; Nordmann, Patrice

In: Diagnostic Microbiology and Infectious Disease, 2020, vol. 98, no. 3, p. 115127

The Revogene® Carba C assay is a real-time polymerase chain reaction–based assay that runs on the microfluidic Revogene platform. It was recently designed for the detection of genes encoding the 5 major carbapenemases (NDM, VIM, IMP, KPC, and OXA-48) from various Gram-negatives. A total of 145 clinical Gram-negative strains (96 carbapenemase producers and 49 non–carbapenemase producers)...

Diabetes mellitus is a risk factor for prolonged SARS-CoV-2 viral shedding in lower respiratory tract samples of critically ill patients

Buetti, Niccolò ; Trimboli, Pierpaolo ; Mazzuchelli, Timothy ; Lo Priore, Elia ; Balmelli, Carlo ; Trkola, Alexandra ; Conti, Marco ; Martinetti, Gladys ; Elzi, Luigia ; Ceschi, Alessandro ; Consonni, Vera ; Ogna, Adam ; Forni-Ogna, Valentina ; Bernasconi, Enos

In: Endocrine, 2020, p. 7 p

The length of time a critically ill coronavirus disease 2019 (COVID-19) patient remains infectious and should therefore be isolated remains unknown. This prospective study was undertaken in critically ill patients to evaluate the reliability of single negative real-time polymerase chain reaction (RT-PCR) in lower tracheal aspirates (LTA) in predicting a second negative test and to analyze...

Antimicrobial effects of antipyretics

Zimmermann, Petra ; Curtis, Nigel

In: Antimicrobial Agents and Chemotherapy, 2017, vol. 61, no. 4, p. -

Antipyretics are some of the most commonly used drugs. Since they are often coadministered with antimicrobial therapy, it is important to understand the interactions between these two classes of drugs. Our review is the first to summarize the antimicrobial effects of antipyretic drugs and the underlying mechanisms involved. Antipyretics can inhibit virus replication, inhibit or promote...

Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone

Pickett, Julie E. ; Thompson, John M. ; Sadowska, Agnieszka ; Tkaczyk, Christine ; Sellman, Bret R. ; Minola, Andrea ; Corti, Davide ; Lanzavecchia, Antonio ; Miller, Lloyd S. ; Thorek, Daniel LJ

In: Bone research, 2018, vol. 6, p. 13

Discriminating sterile inflammation from infection, especially in cases of aseptic loosening versus an actual prosthetic joint infection, is challenging and has significant treatment implications. Our goal was to evaluate a novel human monoclonal antibody (mAb) probe directed against the Gram-positive bacterial surface molecule lipoteichoic acid (LTA). Specificity and affinity were assessed in...

Characterization of the staphylococcal cassette chromosome mec insertion site in 108 isolates lacking the mecA gene and identified as methicillin-resistant Staphylococcus aureus by the Xpert MRSA assay

Stojanov, M. ; Blanc, D.

In: European Journal of Clinical Microbiology & Infectious Diseases, 2014, vol. 33, no. 11, p. 1967-1971

Electronic cigarettes: it is urgent to promote them to save lives

Flahault, Antoine ; Etter, Jean-François

In: International Journal of Public Health, 2014, vol. 59, no. 5, p. 681-682

Characteristics and treatment outcomes of 69 cases with early prosthetic joint infections of the hip and knee

Achermann, Y. ; Stasch, P. ; Preiss, S. ; Lucke, K. ; Vogt, M.

In: Infection, 2014, vol. 42, no. 3, p. 511-519