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Università della Svizzera italiana

Does health literacy reinforce disease knowledge gain? : a prospective observational study of hungarian COPD patients

Papp-Zipernovszky, Orsolya ; Csabai, Márta ; Schulz, Peter J. ; Varga, János T.

In: Journal of clinical medicine, 2021, vol. 10, no. 17, p. 13

We set out to measure the health literacy (HL) of COPD patients using the Short Test of Functional Health Literacy (S- TOFHLA), perception-based screening questions (BHLS), and a specific disease knowledge test (COPD-Q). Our main focus is the relationship between functional HL and patients’ disease-knowledge, which contributes to the clarification of the relationship between the different...

Université de Fribourg

Role of akt activation in PARP inhibitor resistance in cancer

Gallyas, Ferenc ; Sumegi, Balazs ; Szabo, Csaba

In: Cancers, 2020, vol. 12, no. 3, p. 532

Poly(ADP-ribose) polymerase (PARP) inhibitors have recently been introduced in the therapy of several types of cancers not responding to conventional treatments. However, de novo and acquired PARP inhibitor resistance is a significant limiting factor in the clinical therapy, and the underlying mechanisms are not fully understood. Activity of the cytoprotective phosphatidylinositol-3 kinase...

Consortium of Swiss Academic Libraries

Estimates on the zeros of $$E_2$$ E 2

Imamoḡlu, Özlem ; Jermann, Jonas ; Tóth, Árpád

In: Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg, 2014, vol. 84, no. 1, p. 123-138

Université de Fribourg

PARP inhibition induces Akt-mediated cytoprotective effects through the formation of a mitochondria-targeted phospho-ATM-NEMO-Akt-mTOR signalosome

Tapodi, Antal ; Bognar, Zita ; Szabo, Csaba ; Gallyas, Ferenc ; Sumegi, Balázs ; Hocsak, Enikő

In: Biochemical Pharmacology, 2019, vol. 162, p. 98–108

The cytoprotective effect of poly(ADP-ribose) polymerase 1 (PARP1) inhibition is well documented in various cell types subjected to oxidative stress. Previously, we have demonstrated that PARP1 inhibition activates Akt, and showed that this response plays a critical role in the maintenance of mitochondrial integrity and in cell survival. However, it has not yet been defined how nuclear PARP1...

Université de Fribourg

Deciphering the biology of Cryptophyllachora eurasiatica gen. et sp. nov., an often cryptic pathogen of an allergenic weed, Ambrosia artemisiifolia

Kiss, Levente ; Kovács, Gábor M. ; Bóka, Károly ; Bohár, Gyula ; Bohárné, Krisztina Varga ; Németh, Márk Z. ; Takamatsu, Susumu ; Shin, Hyeon-Dong ; Hayova, Vera ; Nischwitz, Claudia ; Seier, Marion K. ; Evans, Harry C. ; Cannon, Paul F. ; Ash, Gavin James ; Shivas, Roger G. ; Müller-Schärer, Heinz

In: Scientific Reports, 2018, vol. 8, no. 1, p. 10806

A little known, unculturable ascomycete, referred to as Phyllachora ambrosiae, can destroy the inflorescences of Ambrosia artemisiifolia, an invasive agricultural weed and producer of highly allergenic pollen. The fungus often remains undetectable in ragweed populations. This work was conducted to understand its origin and pathogenesis, a prerequisite to consider its potential as a biocontrol...

Consortium of Swiss Academic Libraries

Degenerate Crossing Numbers

Pach, János ; Tóth, Géza

In: Discrete & Computational Geometry, 2009, vol. 41, no. 3, p. 376-384