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Inferring the age difference in HIV transmission pairs by applying phylogenetic methods on the HIV transmission network of the Swiss HIV Cohort Study

Kusejko, Katharina ; Kadelka, Claus ; Marzel, Alex ; Battegay, Manuel ; Bernasconi, Enos ; Calmy, Alexandra ; Cavassini, Matthias ; Hoffmann, Matthias ; Böni, Jürg ; Yerly, Sabine ; Klimkait, Thomas ; Perreau, Matthieu ; Rauch, Andri ; Günthard, Huldrych F. ; Kouyos, Roger D. ; Scherrer, Alexandra ; Wild, Susanne ; Perraudin, Danièle ; Minichiello, Mirjam ; Anagnostopoulos, A. ; Battegay, M. ; Bernasconi, E. ; Böni, J. ; Braun, D L. ; Bucher, H C. ; Calmy, A. ; Cavassini, M. ; Ciuffi, A. ; Dollenmaier, G. ; Egger, M. ; Elzi, L. ; Fehr, J. ; Fellay, J. ; Furrer, H. ; Fux, C A. ; Günthard, H F. ; Haerry, D. ; Hasse, B. ; Hirsch, H H. ; Hoffmann, M. ; Hösli, I. ; Huber, M. ; Kahlert, C. ; Kaiser, L. ; Keiser, O. ; Klimkait, T. ; Kouyos, R D. ; Kovari, H. ; Ledergerber, B. ; Martinetti, G. ; Martinez de Tejada, B. ; Marzolini, C. ; Metzner, K J. ; Müller, N. ; Nicca, D. ; Paioni, P. ; Pantaleo, G. ; Perreau, M. ; Rauch, A. ; Rudin, C. ; Scherrer, A U. ; Schmid, P. ; Speck, R. ; Stöckle, M. ; Tarr, P. ; Trkola, A. ; Vernazza, P. ; Wandeler, G. ; Weber, R. ; Yerly, S Morover ; Scherrer, Alexandra ; Wild, Susanne ; Perraudin, Danièle ; Minichiello, Mirjam ; Anagnostopoulos, A. ; Battegay, M. ; Bernasconi, E. ; Böni, J. ; Braun, D L. ; Bucher, H C. ; Calmy, A. ; Cavassini, M. ; Ciuffi, A. ; Dollenmaier, G. ; Egger, M. ; Elzi, L. ; Fehr, J. ; Fellay, J. ; Furrer, H. ; Fux, C A. ; Günthard, H F. ; Haerry, D. ; Hasse, B. ; Hirsch, H H. ; Hoffmann, M. ; Hösli, I. ; Huber, M. ; Kahlert, C. ; Kaiser, L. ; Keiser, O. ; Klimkait, T. ; Kouyos, R D. ; Kovari, H. ; Ledergerber, B. ; Martinetti, G. ; Martinez de Tejada, B. ; Marzolini, C. ; Metzner, K J. ; Müller, N. ; Nicca, D. ; Paioni, P. ; Pantaleo, G. ; Perreau, M. ; Rauch, A. ; Rudin, C. ; Scherrer, A U. ; Schmid, P. ; Speck, R. ; Stöckle, M. ; Tarr, P. ; Trkola, A. ; Vernazza, P. ; Wandeler, G. ; Weber, R. ; Yerly, S Morover

In: Virus Evolution, 2018, vol. 4, no. 2, p. -

Université de Fribourg

Swiss consensus recommendations on urinary tract infections in children

Buettcher, Michael ; Trueck, Johannes ; Niederer-Loher, Anita ; Heininger, Ulrich ; Agyeman, Philipp ; Asner, Sandra ; Berger, Christoph ; Bielicki, Julia ; Kahlert, Christian ; Kottanattu, Lisa ; Meyer Sauteur, Patrick M. ; Paioni, Paolo ; Posfay-Barbe, Klara ; Relly, Christa ; Ritz, Nicole ; Zimmermann, Petra ; Zucol, Franziska ; Gobet, Rita ; Shavit, Sandra ; Rudin, Christoph ; Laube, Guido ; von Vigier, Rodo ; Neuhaus, Thomas J.

In: European Journal of Pediatrics, 2020, p. -

The kidneys and the urinary tract are a common source of infection in children of all ages, especially infants and young children. The main risk factors for sequelae after urinary tract infections (UTI) are congenital anomalies of the kidney and urinary tract (CAKUT) and bladder-bowel dysfunction. UTI should be considered in every child with fever without a source. The differentiation between...

Université de Fribourg

Breast milk microbiota: A review of the factors that influence composition

Zimmermann, Petra ; Curtis, Nigel

In: Journal of Infection, 2020, vol. 81, no. 1, p. 17–47

Breastfeeding is associated with considerable health benefits for infants. Aside from essential nutrients, immune cells and bioactive components, breast milk also contains a diverse range of microbes, which are important for maintaining mammary and infant health. In this review, we summarise studies that have investigated the composition of the breast milk microbiota and factors that might...

Université de Fribourg

Study protocol for the ABERRANT study: antibiotic-induced disruption of the maternal and infant microbiome and adverse health outcomes — a prospective cohort study among children born at term

Volery, Maryse ; Scherz, Valentin ; Jakob, William ; Bandeira, Diane ; Deggim-Messmer, Vanessa ; Lauber-Biason, Anna ; Wildhaber, Johannes ; Falquet, Laurent ; Curtis, Nigel ; Zimmermann, Petra

In: BMJ Open, 2020, vol. 10, no. 6, p. e036275

Introduction: There is compositional overlap between the maternal intestinal microbiome, the breast milk microbiome and the infant oral and intestinal microbiome. Antibiotics cause profound changes in the microbiome. However, the effect of intrapartum and early-life antibiotics on the maternal intestinal and breast milk microbiome, and the infant oral and intestinal microbiome, and whether...

Université de Fribourg

Coronavirus infections in children including covid-19: an overview of the epidemiology, clinical features, diagnosis, treatment and prevention options in children

Petra, Zimmermann ; Nigel, Curtis

In: The Pediatric Infectious Disease Journal, 2020, vol. 39, no. 5, p. 355–368

Coronaviruses (CoVs) are a large family of enveloped, single-stranded, zoonotic RNA viruses. Four CoVs commonly circulate among humans: HCoV2-229E, -HKU1, -NL63 and -OC43. However, CoVs can rapidly mutate and recombine leading to novel CoVs that can spread from animals to humans. The novel CoVs severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002 and Middle East...

Université de Fribourg

The immunomodulatory effects of macrolides - a systematic review of the underlying mechanisms

Zimmermann, Petra ; Ziesenitz, Victoria C. ; Curtis, Nigel ; Ritz, Nicole

In: Frontiers in Immunology, 2018, vol. 9, p. -

The mechanisms underlying the non-antimicrobial immunomodulatory properties of macrolides are not well understood.Objectives: To systematically review the evidence for the immunomodulatory properties of macrolides in humans and to describe the underlying mechanism and extent of their influence on the innate and adaptive immune system.Methods: A systematic literature search was done in MEDLINE...

Université de Fribourg

The effect of maternal immunisation during pregnancy on infant vaccine responses

Zimmermann, Petra ; Perrett, Kirsten P. ; Messina, Nicole L. ; Donatha, Susan ; Ritz, Nicole ; Klis, Fiona R. M. van der ; Curtis, Nigel

In: EClinicalMedicine, 2019, vol. 13, p. 21–30

Immunisation during pregnancy to protect infants against tetanus, pertussis and influenza is recommended in many countries. However, maternal antibodies can interfere with infant vaccine responses. We investigated the effect of antenatal diphtheria-tetanus-acellular pertussis (dTpa) and trivalent inactivated influenza (TIV) immunisation on specific and heterologous antibody responses to...