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Granzyme B attenuates bacterial virulence by targeting secreted factors

López León, Diego ; Matthey, Patricia ; Fellay, Isabelle ; Blanchard, Marianne ; Martinvalet, Denis ; Mantel, Pierre-Yves ; Filgueira, Luis ; Walch, Michael

In: iScience, 2020, vol. 23, no. 3, p. 100932

Pathogenic bacteria secrete virulence factors that interact with the human host to establish infections. The human immune system evolved multiple mechanisms to fight bacterial invaders, including immune proteases that were demonstrated to contribute crucially to antibacterial defense. Here we show that granzyme B degrades multiple secreted virulence mediators from Listeria monocytogenes,...

Large-scale comparison of toxin and antitoxins in Listeria monocytogenes

Agüero, José Antonio ; Akarsu, Hatice ; Aguilar-Bultet, Lisandra ; Oevermann, Anna ; Falquet, Laurent

In: Toxins, 2020, vol. 12, no. 1, p. 29

Toxin–antitoxin systems (TASs) are widely distributed in prokaryotes and encode pairs of genes involved in many bacterial biological processes and mechanisms, including pathogenesis. The TASs have not been extensively studied in Listeria monocytogenes (Lm), a pathogenic bacterium of the Firmicutes phylum causing infections in animals and humans. Using our recently published TASmania...

Regulation of TRPM8 channel activity by Src-mediated tyrosine phosphorylation

Manolache, Alexandra ; Selescu, Tudor ; Maier, G. Larisa ; Mentel, Mihaela ; Ionescu, Aura Elena ; Neacsu, Cristian ; Babes, Alexandru ; Szedlacsek, Stefan Eugen

In: Journal of Cellular Physiology, 2019, p. -

The transient receptor potential melastatin type 8 (TRPM8) receptor channel is expressed in primary afferent neurons where it is the main transducer of innocuous cold temperatures and also in a variety of tumors, where it is involved in progression and metastasis. Modulation of this channel by intracellular signaling pathways has therefore important clinical implications. We investigated the...

How the interaction of Listeria monocytogenes and Acanthamoeba spp. affects growth and distribution of the food borne pathogen

Schuppler, Markus

In: Applied Microbiology and Biotechnology, 2014, vol. 98, no. 7, p. 2907-2916

Acanthamoeba release compounds which promote growth of Listeria monocytogenes and other bacteria

Fieseler, Lars ; Doyscher, Dominik ; Loessner, Martin ; Schuppler, Markus

In: Applied Microbiology and Biotechnology, 2014, vol. 98, no. 7, p. 3091-3097

Listeria bacteriophage peptidoglycan hydrolases feature high thermoresistance and reveal increased activity after divalent metal cation substitution

Schmelcher, Mathias ; Waldherr, Florian ; Loessner, Martin

In: Applied Microbiology and Biotechnology, 2012, vol. 93, no. 2, p. 633-643

Low-P tolerance by maize (Zea mays L.) genotypes: Significance of root growth, and organic acids and acid phosphatase root exudation

Gaume, Alain ; Mächler, Felix ; De León, Carlos ; Narro, Luis ; Frossard, Emmanuel

In: Plant and Soil, 2001, vol. 228, no. 2, p. 253-264

Letter to the Editor: Backbone resonance assignment of the 298 amino acid catalytic domain of protein tyrosine phosphatase 1B (PTP1B)

Meier, Sebastian ; Li, Yu-Chin ; Koehn, James ; Vlattas, Isidoros ; Wareing, James ; Jahnke, Wolfgang ; Wennogle, Lawrence ; Grzesiek, Stephan

In: Journal of Biomolecular NMR, 2002, vol. 24, no. 2, p. 165-166

Application of bacteriophages for detection and control of foodborne pathogens

Hagens, Steven ; Loessner, Martin

In: Applied Microbiology and Biotechnology, 2007, vol. 76, no. 3, p. 513-519

Protein phosphatases and their potential implications in neuroprotective processes

Gee, C. ; Mansuy, I.

In: Cellular and Molecular Life Sciences CMLS, 2005, vol. 62, no. 10, p. 1120-1130