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Università della Svizzera italiana

Reporting of acute inflammatory neuropathies with COVID-19 vaccines : subgroup disproportionality analyses in VigiBase

Noseda, Roberta ; Ripellino, Paolo ; Ghidossi, Sara ; Bertoli, Raffaela ; Ceschi, Alessandro

In: Vaccines, 2021, vol. 9, no. 9, p. 7

Since marketing authorization, cases of neuralgic amyotrophy (NA), facial paralysis/Bell’s palsy (FP/BP), and Guillain-Barré syndrome (GBS) were reported with COVID-19 vaccines of different technologies. This study aimed to assess whether NA, FP/BP, and GBS were more frequently reported in VigiBase with COVID-19 vaccines (of any technologies) than with other viral vaccines, over the full...

Università della Svizzera italiana

The antibody response to Plasmodium falciparum : cues for vaccine design and the discovery of receptor-based antibodies

Tan, Joshua ; Piccoli, Luca ; Lanzavecchia, Antonio

In: Annual Review of Immunology

P. falciparum remains a serious public health problem and a continuous challenge for the immune system due to the complexity and diversity of the pathogen. Recent advances from several laboratories in the characterization of the antibody response to the parasite have led to the identification of critical targets for protection and revealed a new mechanism of diversification based on the...

Université de Fribourg

Effects of continuous theta burst stimulation over the left DLPFC on mother tongue and second language production in late bilinguals: a behavioral and ERP study

Jost, Lea B. ; Pestalozzi, Maria I. ; Cazzoli, Dario ; Mouthon, Michael ; Müri, René M. ; Annoni, Jean‑Marie

In: Brain Topography, 2020, vol. 33, no. 4, p. 504–518

Clinical, neuroimaging, and non-invasive brain stimulation studies have associated the dorsolateral prefrontal cortex (DLPFC) with the multilingual language control system. Here, we investigated if this role is increased during the processing of the non- dominant language due to the higher cognitive/attentional demands. We used an inhibitory repetitive transcranial magnetic stimulation (rTMS)...

Université de Fribourg

Are integrins still practicable targets for anti-cancer therapy?

Alday-Parejo, Begoña ; Stupp, Roger ; Rüegg, Curzio

In: Cancers, 2019, vol. 11, no. 7, p. 978

Correlative clinical evidence and experimental observations indicate that integrin adhesion receptors, in particular those of the αV family, are relevant to cancer cell features, including proliferation, survival, migration, invasion, and metastasis. In addition, integrins promote events in the tumor microenvironment that are critical for tumor progression and metastasis, including tumor...

Università della Svizzera italiana

Schwann cells ER-associated degradation contributes to myelin maintenance in adult nerves and limits demyelination in CMT1B mice

Volpi, Vera G. ; Ferri, Cinzia ; Fregno, Ilaria ; Del Carro, Ubaldo ; Bianchi, Francesca ; Scapin, Cristina ; Pettinato, Emanuela ; Solda, Tatiana ; Feltri, M. Laura ; Molinari, Maurizio ; Wrabetz, Lawrence ; D’Antonio, Maurizio

In: PLOS genetics, 2019, vol. 15, no. 4, p. e1008069

In the peripheral nervous system (PNS) myelinating Schwann cells synthesize large amounts of myelin protein zero (P0) glycoprotein, an abundant component of peripheral nerve myelin. In humans, mutations in P0 cause the demyelinating Charcot-Marie-Tooth 1B (CMT1B) neuropathy, one of the most diffused genetic disorders of the PNS. We previously showed that several mutations, such as the...