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Genetic features leading to reduced susceptibility to aztreonam-avibactam among metallo-β-lactamase-producing escherichia coli isolates

Sadek, Mustafa ; Juhas, Mario ; Poirel, Laurent ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2020, vol. 64, no. 2020-12, p. -

Metallo-β-lactamase (MBL)-producing Escherichia coli isolates resistant to the newly developed β-lactam/β-lactamase inhibitor drug combination aztreonam-avibactam (ATM-AVI) have been reported. Here, we analyzed a series of 118 clinical MBL- producing E. coli isolates of various geographical origins for susceptibility to ATM-AVI. The nature of the PBP3 protein sequence and the occurrence of...

Characterization of FosL1, a plasmid-encoded fosfomycin resistance protein identified in Escherichia coli

Kieffer, Nicolas ; Poirel, Laurent ; Descombes, Marie-Christine ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2020, vol. 64, no. 4, p. -

Fosfomycin is gaining renewed interest for treating urinary tract infections. Monitoring fosfomycin resistance is therefore important in order to detect the emergence of novel resistance mechanisms. Here, we used the Rapid Fosfomycin NP test to screen a collection of extended-spectrum-β-lactamase- producing Escherichia coli isolates from Switzerland and found a fosfomycin- resistant isolate...

Rapid detection of fosfomycin resistance in Escherichia coli

Nordmann, Patrice ; Poirel, Laurent ; Mueller, Linda

In: Journal of Clinical Microbiology, 2019, vol. 57, no. 1, p. e01531-18

The rapid fosfomycin/Escherichia coli NP test was developed to detect fosfomycin resistance in E. coli isolates. The test is based on glucose metabolization and the detection of bacterial growth in the presence of fosfomycin at 40 µg/ml. Bacterial growth is visually detectable by an orange-to-yellow color change of red phenol, a pH indicator. A total of 100 E. coli isolates, among which 22...

Antimicrobial Resistance in Escherichia coli

Poirel, Laurent ; Madec, Jean-Yves ; Lupo, Agnese ; Schink, Anne-Kathrin ; Kieffer, Nicolas ; Nordmann, Patrice ; Schwarz, Stefan

In: Microbiology Spectrum, 2018, vol. 6, no. 4, p. -

Multidrug resistance in Escherichia coli has become a worrying issue that is increasingly observed in human but also in veterinary medicine worldwide. E. coli is intrinsically susceptible to almost all clinically relevant antimicrobial agents, but this bacterial species has a great capacity to accumulate resistance genes, mostly through horizontal gene transfer. The most problematic...

Expression of PHA polymerase genes of Pseudomonas putida in Escherichia coli and its effect on PHA formation

Ren, Qun ; Beilen, Jan ; Sierro, Nicolas ; Zinn, Manfred ; Kessler, Birgit ; Witholt, Bernard

In: Antonie van Leeuwenhoek, 2005, vol. 87, no. 2, p. 91-100

Biochemical, ECF18R , and RYR1 Gene Polymorphisms and Their Associations with Osteochondral Diseases and Production Traits in Pigs

Kadarmideen, Haja

In: Biochemical Genetics, 2008, vol. 46, no. 1-2, p. 41-53

Poly(3-hydroxyalkanoate) polymerase synthesis and in vitro activity in recombinant Escherichia coli and Pseudomonas putida

Ren, Qun ; de Roo, Guy ; van Beilen, Jan ; Zinn, Manfred ; Kessler, Birgit ; Witholt, Bernard

In: Applied Microbiology and Biotechnology, 2005, vol. 69, no. 3, p. 286-292

Overexpression of the ATP-dependent helicase RecG improves resistance to weak organic acids in Escherichia coli

Steiner, P. ; Sauer, U.

In: Applied Microbiology and Biotechnology, 2003, vol. 63, no. 3, p. 293-299

Changes in antimicrobial resistance of Escherichia coli causing urinary tract infections in hospitalized children

Fritzsche, M. ; Ammann, R.A. ; Droz, S. ; Bianchetti, M.G. ; Aebi, C.

In: European Journal of Clinical Microbiology and Infectious Diseases, 2005, vol. 24, no. 3, p. 233-235

Efficient Enzymatic Production of the Bacterial Second Messenger c-di-GMP by the Diguanylate Cyclase YdeH from E. coli

Zähringer, Franziska ; Massa, Claudia ; Schirmer, Tilman

In: Applied Biochemistry and Biotechnology, 2011, vol. 163, no. 1, p. 71-79