Affiner les résultats

An immature B cell population from peripheral blood serves as surrogate marker for monitoring tumor angiogenesis and anti-angiogenic therapy in mouse models

Fagiani, Ernesta ; Bill, Ruben ; Pisarsky, Laura ; Ivanek, Robert ; Rüegg, Curzio ; Christofori, Gerhard

In: Angiogenesis, 2015, vol. 18, no. 3, p. 327-345

6-Thioguanine-loaded polymeric micelles deplete myeloid-derived suppressor cells and enhance the efficacy of T cell immunotherapy in tumor-bearing mice

Jeanbart, Laura ; Kourtis, Iraklis ; van der Vlies, André ; Swartz, Melody ; Hubbell, Jeffrey

In: Cancer Immunology, Immunotherapy, 2015, vol. 64, no. 8, p. 1033-1046

The antibody-mediated targeted delivery of interleukin-13 to syngeneic murine tumors mediates a potent anticancer activity

Hess, Christian ; Neri, Dario

In: Cancer Immunology, Immunotherapy, 2015, vol. 64, no. 5, p. 635-644

TGFBI modulates tumour hypoxia and promotes breast cancer metastasis

Fico, Flavia ; Santamaria‐Martínez, Albert

In: Molecular Oncology, 2020, vol. 14, no. 12, p. 3198–3210

Breast cancer metastasis is a complex process that depends not only on intrinsic characteristics of metastatic stem cells, but also on the particular microenvironment that supports their growth and modulates the plasticity of the system. In search for microenvironmental factors supporting cancer stem cell (CSC) growth and tumour progression to metastasis, we here investigated the role of the...

Increased uptake of silica nanoparticles in inflamed macrophages but not upon co-exposure to micron-sized particles

Susnik, Eva ; Taladriz-Blanco, Patricia ; Drasler, Barbara ; Balog, Sandor ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Cells, 2020, vol. 9, no. 9, p. 2099

Silica nanoparticles (NPs) are widely used in various industrial and biomedical applications. Little is known about the cellular uptake of co-exposed silica particles, as can be expected in our daily life. In addition, an inflamed microenvironment might affect a NP’s uptake and a cell’s physiological response. Herein, prestimulated mouse J774A.1 macrophages with bacterial...

Particle surfaces to study macrophage adherence, migration, and clearance

Septiadi, Dedy ; Lee, Aaron ; Spuch‐Calvar, Miguel ; Moore, Thomas Lee ; Spiaggia, Giovanni ; Abdussalam, Wildan ; Rodriguez‐Lorenzo, Laura ; Taladriz‐Blanco, Patricia ; Rothen‐Rutishauser, Barbara ; Petri‐Fink, Alke

In: Advanced Functional Materials, 2020, p. 2002630

Nanoparticle adsorption to substrates pose a unique challenge to understand uptake mechanisms as it involves the organization of complex cytoskeletal components by cells to perform endocytosis/phagocytosis. In particular, it is not well‐understood from a cell mechanics perspective how the adhesion of particles on substrate will influence the ease of material clearance. By using a particle...

The microtubule-depolymerizing agent ansamitocin P3 programs dendritic cells toward enhanced anti-tumor immunity

Martin, Kea ; Müller, Philipp ; Schreiner, Jens ; Prince, Spasenija ; Lardinois, Didier ; Heinzelmann-Schwarz, Viola ; Thommen, Daniela ; Zippelius, Alfred

In: Cancer Immunology, Immunotherapy, 2014, vol. 63, no. 9, p. 925-938

Preclinical evaluation of IL2-based immunocytokines supports their use in combination with dacarbazine, paclitaxel and TNF-based immunotherapy

Pretto, Francesca ; Elia, Giuliano ; Castioni, Nadia ; Neri, Dario

In: Cancer Immunology, Immunotherapy, 2014, vol. 63, no. 9, p. 901-910

Characterization and in vivo validation of a three-dimensional multi-cellular culture model to study heterotypic interactions in colorectal cancer cell growth, invasion and metastasis

Cattin, Sarah ; Ramont, Laurent ; Rüegg, Curzio

In: Frontiers in Bioengineering and Biotechnology, 2018, vol. 6, p. -

Colorectal cancer (CRC) is the third cause of cancer-related mortality in industrialized countries. Local invasion and metastasis formation are events associated with poor prognosis for which today there are no effective therapeutic options. Invasion and metastasis are strongly modulated by cells of the tumor microenvironment (TME), in particular fibroblasts and endothelial cells. Unraveling...

Reactive oxygen species and nitric oxide in viral diseases

Peterhans, Ernst

In: Biological Trace Element Research, 1997, vol. 56, no. 1, p. 107-116