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Université de Fribourg

Estimating glacier-bed overdeepenings as possible sites of future lakes in the de-glaciating Mont Blanc massif (Western European Alps)

Magnin, F. ; Haeberli, W. ; Linsbauer, Andreas ; Deline, P. ; Ravanel, L.

In: Geomorphology, 2020, vol. 350, p. 106913

De-glaciating high mountain areas result in new landscapes of bedrock and debris where permafrost can degrade, persist or even newly form in cases, and of new lakes in glacier bed overdeepenings (GBOs) becoming ice-free. These landscapes with new lakes in close neighborhood to over-steepened and perennially frozen slopes are prone to chain reaction processes (e.g. rock-ice avalanches into...

Université de Fribourg

Salivary gland macrophages and tissue-resident CD8+ T cells cooperate for homeostatic organ surveillance

Stolp, Bettina ; Thelen, Flavian ; Ficht, Xenia ; Altenburger, Lukas M. ; Ruef, Nora ; Inavalli, V. V. G. Krishna ; Germann, Philipp ; Page, Nicolas ; Moalli, Federica ; Raimondi, Andrea ; Keyser, Kirsten A. ; Jafari, S. Morteza Seyed ; Barone, Francesca ; Dettmer, Matthias S. ; Merkler, Doron ; Iannacone, Matteo ; Sharpe, James ; Schlapbach, Christoph ; Fackler, Oliver T. ; Nägerl, U. Valentin ; Stein, Jens V.

In: Science Immunology, 2020, vol. 5, no. 46, p. eaaz4371

It is well established that tissue macrophages and tissue-resident memory CD8+ T cells (TRM) play important roles for pathogen sensing and rapid protection of barrier tissues. In contrast, the mechanisms by which these two cell types cooperate for homeostatic organ surveillance after clearance of infections is poorly understood. Here, we used intravital imaging to show that TRM dynamically...

Université de Fribourg

Anion-induced structural diversity of Zn and Cd coordination polymers based on bis-9,10-(pyridine-4-yl)-anthracene, their luminescent properties, and highly efficient sensing of nitro derivatives and herbicides

Vasylevskyi, Serhii I. ; Bassani, Dario M. ; Fromm, Katharina M.

In: Inorganic Chemistry, 2019, vol. 58, no. 9, p. 5646–5653

Luminescent coordination polymers (CPs) of Zn2+ or Cd2+ and bis-9,10-(pyridine-4- yl)-anthracene (BA) show different 1D and 2D topologies depending on the anion used in the precursor. Compounds {[Zn(μ2-BA)(MeOH)2(p-Tos)2]}n (1) and {[Zn(μ2- BA)(MeOH)2(CF3CO2)2]}n (2) form linear structures and {BA@[Zn(μ2-BA) (MeOH)2(H2O)2](CF3SO3)2}n (3) featuring intercalation of uncoordinated BA molecules...

Consortium of Swiss Academic Libraries

Local Stereology of Tensors of Convex Bodies

Jensen, Eva ; Ziegel, Johanna

In: Methodology and Computing in Applied Probability, 2014, vol. 16, no. 2, p. 263-282

Université de Fribourg

Removal of a subset of non-essential genes fully attenuates a highly virulent mycoplasma strain

Jores, Joerg ; Ma, Li ; Ssajjakambwe, Paul ; Schieck, Elise ; Liljander, Anne ; Chandran, Suchismita ; Stoffel, Michael H. ; Cippa, Valentina ; Arfi, Yonathan ; Assad-Garcia, Nacyra ; Falquet, Laurent ; Sirand-Pugnet, Pascal ; Blanchard, Alain ; Lartigue, Carole ; Posthaus, Horst ; Labroussaa, Fabien ; Vashee, Sanjay

In: Frontiers in Microbiology, 2019, vol. 10, p. -

Mycoplasmas are the smallest free-living organisms and cause a number of economically important diseases affecting humans, animals, insects, and plants. Here, we demonstrate that highly virulent Mycoplasma mycoides subspecies capri (Mmc) can be fully attenuated via targeted deletion of non-essential genes encoding, among others, potential virulence traits. Five genomic regions, representing...

Université de Fribourg

Acquisition of extended-spectrum β-lactamase GES-6 leading to resistance to ceftolozane-tazobactam combination in Pseudomonas aeruginosa

Poirel, Laurent ; Ortiz De La Rosa, José-Manuel ; Kieffer, Nicolas ; Dubois, Véronique ; Jayol, Aurélie ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2019, vol. 63, no. 1, p. e01809-18

A clinical Pseudomonas aeruginosa isolate resistant to all β-lactams, including ceftolozane-tazobactam and carbapenems, was recovered. It belonged to sequence type 235 and produced the extended-spectrum β-lactamase (ESBL) GES-6 differing from GES-1 by two amino acid substitutions (E104K and G170S). GES-6 possessed an increased hydrolytic activity toward carbapenems and to ceftolozane and a ...

Université de Fribourg

Detection of colistin-resistant Gram-negative rods by using the SuperPolymyxin medium

Jayol, Aurélie ; Poirel, Laurent ; André, Catherine ; Dubois, Véronique ; Nordmann, Patrice

In: Diagnostic Microbiology and Infectious Disease, 2018, vol. 92, no. 2, p. 95–101

The commercial SuperPolymyxin medium (ELITechGroup, Puteaux, France), currently licensed in Europe, is aimed to screen for either intrinsic or acquired colistin resistance in Gram negatives. It was tested for screening colistin-resistant Gram- negative rods from bacterial cultures of 145 colistin-resistant and 86 colistin- susceptible Gram-negative rods isolates. It exhibited a sensitivity and...