In: PLOS Genetics, 2020, vol. 16, no. 11, p. e1008913
Mitotic divisions depend on the timely assembly and proper orientation of the mitotic spindle. Malfunctioning of these processes can considerably delay mitosis, thereby compromising tissue growth and homeostasis, and leading to chromosomal instability. Loss of functional Mms19 drastically affects the growth and development of mitotic tissues in Drosophila larvae and we now demonstrate that...
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In: International journal of molecular sciences, 2017, vol. 18, no. 10, p. 2042
Microtubules are the main components of mitotic spindles, and are the pillars of the cellular cytoskeleton. They perform most of their cellular functions by virtue of their unique dynamic instability processes which alternate between polymerization and depolymerization phases. This in turn is driven by a precise balance between attraction and repulsion forces between the constituents of...
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In: Pharmaceuticals, 2018, vol. 11, no. 1, p. 22
The Toll-Like Receptor 7 (TLR7) is an endosomal membrane receptor involved in the innate immune system response. Its best-known small molecule activators are imidazoquinoline derivatives such as imiquimod (R-837) and resiquimod (R-848). Recently, an interaction between R-837 and the colchicine binding site of tubulin was reported. To investigate the possibility of an interaction between...
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In: BMC structural biology, 2016, vol. 16, p. 17
Background: TPX2 (Targeting Protein for Xklp2) is essential for spindle assembly, activation of the mitotic kinase Aurora A and for triggering microtubule nucleation. Homologs of TPX2 in Chordata and plants were previously identified. Currently, proteins of the TPX2 family have little structural information and only small parts are covered by defined protein domains. Methods: We have used ...
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In: Catalysis Letters, 2006, vol. 109, no. 1-2, p. 49-53
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In: Current Genetics, 2008, vol. 53, no. 2, p. 107-115
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In: Cellular and Molecular Life Sciences, 2010, vol. 67, no. 13, p. 2145-2161
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In: Psychopharmacology, 2010, vol. 208, no. 4, p. 531-543
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In: Pediatric Surgery International, 2011, vol. 27, no. 3, p. 241-247
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In: Nanoscale, 2017, vol. 9, no. 38, p. 14405-14413
We describe the synthesis of hybrid magnetic ellipsoidal nanoparticles that consist of a mixture of two different iron oxide phases, hematite (α-Fe2O3) and maghemite (γ- Fe2O3), and characterize their magnetic field-driven self-assembly. We demonstrate that the relative amount of the two phases can be adjusted in a continuous way by varying the reaction time during the synthesis, leading to...
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