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Université de Fribourg

Review of emerging japanese encephalitis virus: new aspects and concepts about entry into the brain and inter-cellular spreading

Filgueira, Luis ; Lannes, Nils

In: Pathogens, 2019, vol. 8, no. 3, p. 111

Japanese encephalitis virus (JEV) is an emerging flavivirus of the Asia-Pacific region. More than two billion people live in endemic or epidemic areas and are at risk of infection. Recently, the first autochthonous human case was recorded in Africa, and infected birds have been found in Europe. JEV may spread even further to other continents. The first section of this review covers...

Université de Fribourg

Blocking Independent Sets for H-Free Graphs via Edge Contractions and Vertex Deletions

Paulusma, Daniël ; Picouleau, Christophe ; Ries, Bernard

In: Lecture Notes in Computer Science, 2017, vol. 10185, p. 470-483

Let d and k be two given integers, and let G be a graph. Can we reduce the independence number of G by at least d via at most k graph operations from some fixed set S? This problem belongs to a class of so-called blocker problems. It is known to be co-NP-hard even if S consists of either an edge contraction or a vertex deletion. We further investigate its computational complexity under these...

Université de Fribourg

Ecdysone triggered PGRP‐LC expression controls Drosophila innate immunity

Rus, Florentina ; Flatt, Thomas ; Tong, Mei ; Aggarwal, Kamna ; Okuda, Kendi ; Kleino, Anni ; Yates, Elisabeth ; Tatar, Marc ; Silverman, Neal

In: The EMBO Journal, 2013, vol. 32, no. 11, p. 1626–1638

Throughout the animal kingdom, steroid hormones have been implicated in the defense against microbial infection, but how these systemic signals control immunity is unclear. Here, we show that the steroid hormone ecdysone controls the expression of the pattern recognition receptor PGRP‐LC in Drosophila, thereby tightly regulating innate immune recognition and defense against bacterial...