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Clinical value of SPECT/CT in the painful total knee arthroplasty (TKA): a prospective study in a consecutive series of 100 TKA

Hirschmann, Michael ; Amsler, Felix ; Rasch, Helmut

In: European Journal of Nuclear Medicine and Molecular Imaging, 2015, vol. 42, no. 12, p. 1869-1882

Multilocular sinonasal malignant melanoma: a poor prognostic subgroup?

Stanimirov Rossi, O. ; Vital, Domenic ; Soyka, M. ; Roth, T. ; Huber, G. ; Holzmann, D.

In: European Archives of Oto-Rhino-Laryngology, 2015, vol. 272, no. 1, p. 123-129

Mutations in the polyglutamylase gene TTLL5, expressed in photoreceptor cells and spermatozoa, are associated with cone-rod degeneration and reduced male fertility

Bedoni, Nicola ; Haer-Wigman, Lonneke ; Vaclavik, Veronika ; Tran, Viet H. ; Farinelli, Pietro ; Balzano, Sara ; Royer-Bertrand, Beryl ; El-Asrag, Mohammed E. ; Bonny, Olivier ; Ikonomidis, Christos ; Litzistorf, Yan ; Nikopoulos, Konstantinos ; Yioti, Georgia G. ; Stefaniotou, Maria I. ; McKibbin, Martin ; Booth, Adam P. ; Ellingford, Jamie M. ; Black, Graeme C. ; Toomes, Carmel ; Inglehearn, Chris F. ; Hoyng, Carel B. ; Bax, Nathalie ; Klaver, Caroline C.W. ; Thiadens, Alberta A. ; Murisier, Fabien ; Schorderet, Daniel F. ; Ali, Manir ; Cremers, Frans P.M. ; Andréasson, Sten ; Munier, Francis L. ; Rivolta, Carlo

In: Human Molecular Genetics, 2016, vol. 25, no. 20, p. 4546-4555

Complex function of the knee joint: the current understanding of the knee

Hirschmann, Michael ; Müller, Werner

In: Knee Surgery, Sports Traumatology, Arthroscopy, 2015, vol. 23, no. 10, p. 2780-2788

Arginase‐II promotes melanoma migration and adhesion through enhancing hydrogen peroxide production and STAT3 signaling

Yu, Yi ; Ladeiras, Diogo ; Xiong, Yuyan ; Boligan, Kayluz Frias ; Liang, Xiujie ; Gunten, Stephan ; Hunger, Robert E. ; Ming, Xiu‐Fen ; Yang, Zhihong

In: Journal of Cellular Physiology, 2020, p. jcp.29814

Elevated arginase type II (Arg‐II) associates with higher grade tumors. Its function and underlying molecular mechanisms in melanoma remain elusive. In the present study, we observed a significantly higher frequency of Arg‐II expression in melanoma of patients with metastasis than those without metastasis. Silencing Arg‐II in two human melanoma cell lines slowed down the cell growth,...

Frequencies of circulating MDSC correlate with clinical outcome of melanoma patients treated with ipilimumab

Meyer, Christiane ; Cagnon, Laurène ; Costa-Nunes, Carla ; Baumgaertner, Petra ; Montandon, Nicole ; Leyvraz, Loredana ; Michielin, Olivier ; Romano, Emanuela ; Speiser, Daniel

In: Cancer Immunology, Immunotherapy, 2014, vol. 63, no. 3, p. 247-257

Preclinical evaluation of IL2-based immunocytokines supports their use in combination with dacarbazine, paclitaxel and TNF-based immunotherapy

Pretto, Francesca ; Elia, Giuliano ; Castioni, Nadia ; Neri, Dario

In: Cancer Immunology, Immunotherapy, 2014, vol. 63, no. 9, p. 901-910

The use of the EVITA algorithm for clinical assessment of novel agents used in prostate cancer, metastatic melanoma, and systemic lupus erythematosus

Szucs, Thomas ; Puri, Daniele ; Blank, Patricia

In: European Journal of Clinical Pharmacology, 2014, vol. 70, no. 8, p. 983-990

European practical and patient-centred guidelines for adult obesity management in primary care

Durrer Schutz, D. ; Busetto, L. ; Dicker, D. ; Farpour-Lambert, N. ; Pryke, R. ; Toplak, H. ; Widmer, D. ; Yumuk, V. ; Schutz, Yves

In: Obesity Facts, 2019, vol. 12, no. 1, p. 40–66

The first contact for patients with obesity for any medical treatment or other issues is generally with General Practitioners (GPs). Therefore, given the complexity of the disease, continuing GPs’ education on obesity management is essential. This article aims to provide obesity management guidelines specifically tailored to GPs, favouring a practical patient-centred approach. The focus is...

Chemokine receptor patterns in lymphocytes mirror metastatic spreading in melanoma

Jacquelot, Nicolas ; Enot, David P. ; Flament, Caroline ; Vimond, Nadège ; Blattner, Carolin ; Pitt, Jonathan M. ; Yamazaki, Takahiro ; Roberti, María Paula ; Daillère, Romain ; Vétizou, Marie ; Poirier-Colame, Vichnou ; Semeraro, Michaëla ; Caignard, Anne ; Slingluff Jr., Craig L. ; Sallusto, Federica ; Rusakiewicz, Sylvie ; Weide, Benjamin ; Marabelle, Aurélien ; Kohrt, Holbrook ; Dalle, Stéphane ; Cavalcanti, Andréa ; Kroemer, Guido ; Di Giacomo, Anna Maria ; Maio, Michele ; Wong, Phillip ; Yuan, Jianda ; Wolchok, Jedd ; Umansky, Viktor ; Eggermont, Alexander ; Zitvogel, Laurence

In: The journal of clinical investigation, 2016, vol. 126, no. 3, p. 921-937

Melanoma prognosis is dictated by tumor-infiltrating lymphocytes, the migratory and functional behavior of which is guided by chemokine or cytokine gradients. Here, we retrospectively analyzed the expression patterns of 9 homing receptors (CCR/CXCR) in naive and memory CD4+ and CD8+ T lymphocytes in 57 patients with metastatic melanoma (MMel) with various sites of metastases to evaluate...