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Università della Svizzera italiana

Extreme sleep state misperception : from psychopathology to objective-subjective sleep measures

Castelnovo, Anna ; Ferri, Raffaele ; Galbiati, Andrea ; Rossi, Alessandro ; Zucconi, Marco ; Castronovo, Vincenza ; Strambi, Luigi-Ferini ; Manconi, Mauro

In: International journal of psychophysiology, 2021, vol. 167, p. 77-85

Study objectives: We tested the hypothesis that patients with extreme sleep state misperception display higher levels of psychopathology and reduced quantitative estimation abilities compared to other patients with insomnia. Secondary aims included the evaluation of group differences in subjective self-reported quality of life and sleep quality and objective sleep parameters. Methods: In this...

Università della Svizzera italiana

Targeting the DNA damage response for patients with lymphoma : preclinical and clinical evidences

Carrassa, Laura ; Colombo, Ilaria ; Damia, Giovanna ; Bertoni, Francesco

In: Cancer treatment reviews, 2020, vol. 90, p. 11

The DNA damage response (DDR) is a well-coordinated cellular network activated by DNA damage. The unravelling of the key players in DDR, their specific inactivation in different tumor types and the synthesis of specific chemical inhibitors of DDR represent a new hot topic in cancer therapy. In this article, we will review the importance of DDR in lymphoma development and how this can be...

Università della Svizzera italiana

Magnesium metabolism in chronic alcohol-use disorder : meta-analysis and systematic review

Vanoni, Flora O. ; Milani, Gregorio P. ; Agostoni, Carlo ; Treglia, Giorgio ; Faré, Pietro B. ; Camozzi, Pietro ; Lava, Sebastiano A. G. ; Bianchetti, Mario G. ; Janett, Simone

In: Nutrients, 2021, vol. 13, no. 6, p. 11

Chronic alcohol-use disorder has been imputed as a possible cause of dietary magnesium depletion. The purpose of this study was to assess the prevalence of hypomagnesemia in chronic alcohol-use disorder, and to provide information on intracellular magnesium and on its renal handling. We carried out a structured literature search up to November 2020, which returned 2719 potentially relevant...

Università della Svizzera italiana

Vitamin D status in adolescents during COVID-19 pandemic : a cross-sectional comparative study

Meoli, Martina ; Muggli, Franco ; Lava, Sebastiano A. G. ; Bianchetti, Mario G. ; Agostoni, Carlo ; Kocher, Claudine ; Bührer, Thomas W. ; Ciliberti, Letizia ; Simonetti, Giacomo D. ; Milani, Gregorio P.

In: Nutrients, 2021, vol. 13, no. 5, p. 7

Vitamin D has been claimed to be effective in the response to infections, including the respiratory syndrome coronavirus 2 (SARS-CoV-2). It is supposed that lockdown measures and fear of SARS-CoV-2 infection might reduce vitamin D levels through the modification of lifestyle. However, very few data exist on the association between lockdown measures and vitamin D status in humans. For this...

Università della Svizzera italiana

SARS-CoV-2 Ig G among HealthcareWorkers and the General Population

Milani, Gregorio P. ; Bianchetti, Mario G. ; Togni, Giuseppe ; Schoenenberger, Andreas W. ; Muggli, Franco

In: Pathogens, 2021, vol. 10, no. 4, p. 6

It is assumed that healthcare workers are at the highest risk to be infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, few data from healthcare workers who do not primarily take care of patients with SARS-CoV-2 infection support this assumption. We investigated the prevalence of immunoglobulin G (Ig G) against SARS-CoV-2 among healthcare workers who do not...

Università della Svizzera italiana

Dietary chloride deficiency syndrome : pathophysiology, history, and systematic literature review

Signorelli, Giulia C. ; Bianchetti, Mario G. ; Jermini, Luca M. M. ; Agostoni, Carlo ; Milani, Gregorio P. ; Simonetti, Giacomo D. ; Lava, Sebastiano A. G.

In: Nutrients, 2020, vol. 12, no. 11, p. 10 p

Metabolic alkalosis may develop as a consequence of urinary chloride (and sodium) wasting, excessive loss of salt in the sweat, or intestinal chloride wasting, among other causes. There is also a likely underrecognized association between poor salt intake and the mentioned electrolyte and acid–base abnormality. In patients with excessive loss of salt in the sweat or poor salt intake, the...