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Università della Svizzera italiana

International prognostic score for asymptomatic early-stage chronic lymphocytic leukemia

Condoluci, Adalgisa ; Terzi di Bergamo, Lodovico ; Langerbeins, Petra ; Hoechstetter, Manuela A. ; Herling, Carmen D. ; De Paoli, Lorenzo ; Delgado, Julio ; Rabe, Kari G. ; Gentile, Massimo ; Doubek, Michael ; Mauro, Francesca R. ; Chiodin, Giorgia ; Mattsson, Mattias ; Bahlo, Jasmin ; Cutrona, Giovanna ; Kotaskova, Jana ; Deambrogi, Clara ; Smedby, Karin E. ; Spina, Valeria ; Bruscaggin, Alessio ; Wu, Wei ; Moia, Riccardo ; Bianchi, Elena ; Gerber, Bernhard ; Zucca, Emanuele ; Gillessen, Silke ; Ghielmini, Michele ; Cavalli, Franco ; Stussi, Georg ; Hess, Mark A. ; Baumann, Tycho S. ; Neri, Antonino ; Ferrarini, Manlio ; Rosenquist, Richard ; Forconi, Francesco ; Foà, Robin ; Pospisilova, Sarka ; Morabito, Fortunato ; Stilgenbauer, Stephan ; Döhner, Hartmut ; Parikh, Sameer A. ; Wierda, William G. ; Montserrat, Emili ; Gaidano, Gianluca ; Hallek, Michael ; Rossi, Davide

In: Blood, 2020, vol. 135, no. 21, p. 1859–1869

Most patients with chronic lymphocytic leukemia (CLL) are diagnosed with early-stage disease and managed with active surveillance. The individual course of patients with early-stage CLL is heterogeneous, and their probability of needing treatment is hardly anticipated at diagnosis. We aimed at developing an international prognostic score to predict time to first treatment (TTFT) in patients...

Université de Fribourg

Parvalbumin alters mitochondrial dynamics and affects cell morphology

Lichvarova, Lucia ; Henzi, Thomas ; Safiulina, Dzhamilja ; Kaasik, Allen ; Schwaller, Beat

In: Cellular and Molecular Life Sciences, 2018, vol. 75, no. 24, p. 4643–4666

The Ca2+-binding protein parvalbumin (PV) and mitochondria play important roles in Ca2+ signaling, buffering and sequestration. Antagonistic regulation of PV and mitochondrial volume is observed in in vitro and in vivo model systems. Changes in mitochondrial morphology, mitochondrial volume and dynamics (fusion, fission, mitophagy) resulting from modulation of PV were investigated in MDCK...