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Consortium of Swiss Academic Libraries

In memoriam—Walter J. Gehring

Affolter, Markus ; Nigg, Erich

In: Chromosoma, 2015, vol. 124, no. 3, p. 291-291

Université de Fribourg

Granzyme B attenuates bacterial virulence by targeting secreted factors

López León, Diego ; Matthey, Patricia ; Fellay, Isabelle ; Blanchard, Marianne ; Martinvalet, Denis ; Mantel, Pierre-Yves ; Filgueira, Luis ; Walch, Michael

In: iScience, 2020, vol. 23, no. 3, p. 100932

Pathogenic bacteria secrete virulence factors that interact with the human host to establish infections. The human immune system evolved multiple mechanisms to fight bacterial invaders, including immune proteases that were demonstrated to contribute crucially to antibacterial defense. Here we show that granzyme B degrades multiple secreted virulence mediators from Listeria monocytogenes,...

Université de Fribourg

Airborne medicine: bacterial volatiles and their influence on plant health

Garbeva, Paolina ; Weisskopf, Laure

In: New Phytologist, 2019, p. -

Like most other eukaryotes, plants do not live alone but in close association with a diverse microflora. These plant‐associated microbes contribute to plant health in many different ways, ranging from modulation of hormonal pathways to direct antibiosis of plant pathogens. Over the last 15 yr, the importance of volatile organic compounds as mediators of mutualistic interactions between...

Université de Fribourg

A substrate of the ABC transporter PEN3 stimulates bacterial flagellin (flg22)-induced callose deposition in Arabidopsis thaliana

Matern, Andreas ; Böttcher, Christoph ; Eschen-Lippold, Lennart ; Westermann, Bernhard ; Smolka, Ulrike ; Döll, Stefanie ; Trempel, Fabian ; Aryal, Bibek ; Scheel, Dierk ; Geisler, Markus ; Rosahl, Sabine

In: Journal of Biological Chemistry, 2019, vol. 294, no. 17, p. 6857–6870

Nonhost resistance of Arabidopsis thaliana against Phytophthora infestans, a filamentous eukaryotic microbe and the causal agent of potato late blight, is based on a multilayered defense system. Arabidopsis thaliana controls pathogen entry through the penetration-resistance genes PEN2 and PEN3, encoding an atypical myrosinase and an ABC transporter, respectively, required for synthesis and...

Université de Fribourg

Hook length of the bacterial flagellum is optimized for maximal stability of the flagellar bundle

Spöring, Imke ; Martinez, Vincent A. ; Hotz, Christian ; Schwarz-Linek, Jana ; Grady, Keara L. ; Nava-Sedeño, Josué M. ; Vissers, Teun ; Singer, Hanna M. ; Rohde, Manfred ; Bourquin, Carole ; Hatzikirou, Haralampos ; Poon, Wilson C. K. ; Dufour, Yann S. ; Erhardt, Marc

In: PLOS Biology, 2018, vol. 16, no. 9, p. e2006989

Most bacteria swim in liquid environments by rotating one or several flagella. The long external filament of the flagellum is connected to a membrane-embedded basal body by a flexible universal joint, the hook, which allows the transmission of motor torque to the filament. The length of the hook is controlled on a nanometer scale by a sophisticated molecular ruler mechanism. However, why its...