Affiner les résultats

Plazomicin activity against polymyxin-resistant Enterobacteriaceae, including MCR-1-producing isolates

Denervaud-Tendon, Valérie ; Poirel, Laurent ; Connolly, Lynn E. ; Krause, Kevin M. ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2017, vol. 72, no. 10, p. 2787-2791

Emergence of an MDR Klebsiella pneumoniae ST231 producing OXA-232 and RmtF in Switzerland

Mancini, Stefano ; Poirel, Laurent ; Tritten, Marie-Lise ; Lienhard, Reto ; Bassi, Cécile ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2018, vol. 73, no. 3, p. 821-823

Concomitant and multiclonal dissemination of OXA-48-producing Klebsiella pneumoniae in a Spanish hospital

Fernández, Javier ; Poirel, Laurent ; Rodicio, M. Rosario ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2016, vol. 71, no. 6, p. 1734-1736

Klebsiella pneumoniae in a patient with hoarseness and dysphagia rather than pharyngitis

von Graevenitz, Alexander

In: Infection, 2015, vol. 43, no. 3, p. 377-377

Ceftazidime/avibactam alone or in combination with aztreonam against colistin-resistant and carbapenemase-producing Klebsiella pneumoniae

Jayol, Aurélie ; Nordmann, Patrice ; Poirel, Laurent ; Dubois, Véronique

In: Journal of Antimicrobial Chemotherapy, 2018, vol. 73, no. 2, p. 542-544

Cross-border emergence of clonal lineages of ST38 Escherichia coli producing the OXA-48-like carbapenemase OXA-244 in Germany and Switzerland

Falgenhauer, Linda ; Nordmann, Patrice ; Imirzalioglu, Can ; Yao, Yancheng ; Falgenhauer, Jane ; M.Hauri, Anja ; Heinmüller, Petra ; Chakraborty, Trinad

In: International Journal of Antimicrobial Agents, 2020, vol. 56, no. 6, p. 106157

Background: Carbapenemase-producing Gram-negative bacteria cause infections that are difficult to treat and represent a rising threat to healthcare systems worldwide. This study analysed isolates of Escherichia coli (E. coli), a species associated with nosocomial-acquired and community-acquired infections, from hospitals in Germany and Switzerland exhibiting a slight decrease in...

Epidemiology of extended-spectrum β-lactamase-producing Enterobacteriaceae among healthcare students, at the Portuguese Red Cross Health School of Lisbon, Portugal

Fournier, Claudine ; Aires de Sousa, Marta ; Fuster Escriva, Begoña ; Sales, Leila ; Nordmanna, Patrice ; Poirel, Laurent

In: Journal of Global Antimicrobial Resistance, 2020, vol. 22, p. 733–737

Objective: The aim of the present study was to prospectively evaluate the prevalence of intestinal carriage by extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae among Portuguese students attending a Bachelors’ course in healthcare, and to determine the molecular features of ESBL-producing isolates.Methods: One-hundred and eleven faecal samples recovered from Portuguese...

Epidemiology of carbapenemase-producing Klebsiella pneumoniae in northern Portugal: Predominance of KPC-2 and OXA-48

Lopes, Elizeth ; Saavedra, Maria José ; Costa, Eliana ; Lencastre, Hermíniade ; Poirel, Laurent ; Aires-de-Sousa, Marta

In: Journal of Global Antimicrobial Resistance, 2020, vol. 22, p. 349–353

Objectives: To provide, for the first time, data on the molecular epidemiology of carbapenemase-producing Klebsiella pneumoniae clinical isolates from the northern region of Portugal (Trás-os-Montes and Alto Douro).Methods: A total of 106 carbapenemase-producing K. pneumoniae isolates recovered from clinical samples and rectal swabs between January 2018 and March 2019 were included in this...

High-risk KPC-producing Klebsiella pneumoniae lack type I R-M systems

Zhou, Ying ; Tian, Dongxing ; Tang, Yu ; Yu, Lianhua ; Huang, Yunkun ; Li, Gang ; Li, Meng ; Wang, Yong ; Yang, Zehua ; Poirel, Laurent ; Jiang, Xiaofei

In: International Journal of Antimicrobial Agents, 2020, vol. 56, no. 2, p. 106050

Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) have disseminated worldwide and are a major threat to public health. The multidrug- resistant (MDR)-phenotype of KPC-KP are commonly associated with the presence of high molecular weight blaKPC plasmids. Restriction-modification (R-M) systems provide bacteria with innate defense against plasmids or other infectious gene...

ISEcp1 mediated transposition leads to fosfomycin and broad-spectrum cephalosporin resistance in Klebsiella pneumoniae

Kieffer, Nicolas ; Poirel, Laurent ; Mueller, Linda ; Mancini, Stefano ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2020, vol. 64, no. 5, p. -

A fosfomycin-resistant and carbapenemase (OXA-48)-producing Klebsiella pneumoniae isolate was recovered, and whole-genome sequencing revealed ISEcp1-blaCTX-M-14b tandemly inserted upstream of the chromosomally encoded lysR-fosA locus. Quantitative evaluation of the expression of lysR and fosA genes showed that this insertion brought a strong hybrid promoter leading to overexpression of the...