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Dynamic spherical harmonics approach for shape classification of migrating cells

Medyukhina, Anna ; Blickensdorf, Marco ; Cseresnyés, Zoltán ; Ruef, Nora ; Stein, Jens V. ; Figge, Marc Thilo

In: Scientific Reports, 2020, vol. 10, no. 1, p. 6072

Cell migration involves dynamic changes in cell shape. Intricate patterns of cell shape can be analyzed and classified using advanced shape descriptors, including spherical harmonics (SPHARM). Though SPHARM have been used to analyze and classify migrating cells, such classification did not exploit SPHARM spectra in their dynamics. Here, we examine whether additional information from dynamic...

Inducible and reversible silencing of the Pvalb gene in mice: An in vitro and in vivo study

Filice, Federica ; Blum, Walter ; Lauber, Emanuel ; Schwaller, Beat

In: European Journal of Neuroscience, 2019, vol. 50, no. 4, p. 2694–2706

Inducible and reversible regulation of gene expression is a powerful approach for unraveling gene functions. Here, we describe the generation of a system to efficiently downregulate in a reversible and inducible manner the Pvalb gene coding for the calcium‐binding protein parvalbumin (PV) in mice. We made use of an IPTG‐inducible short hairpin RNA to activate Pvalb transcript knockdown...

A clinal polymorphism in the insulin signaling transcription factor foxo contributes to life-history adaptation in Drosophila*

Durmaz, Esra ; Rajpurohit, Subhash ; Betancourt, Nicolas ; Fabian, Daniel K. ; Kapun, Martin ; Schmidt, Paul ; Flatt, Thomas

In: Evolution, 2019, vol. 73, no. 9, p. 1774–1792

A fundamental aim of adaptation genomics is to identify polymorphisms that underpin variation in fitness traits. In Drosophila melanogaster, latitudinal life‐history clines exist on multiple continents and make an excellent system for dissecting the genetics of adaptation. We have previously identified numerous clinal single‐nucleotide polymorphism in insulin/insulin‐like growth factor...

Thomas F. Mayer, The Roman Inquisition on the Stage of Italy, c. 1590-1640. Philadelphia, University of Pennsylvania Press 2014

Siebenhüner, Kim

In: Historische Zeitschrift, 2015, vol. 301, no. 1, p. 225-227

Environmental enrichment eliminates the anxiety phenotypes in a triple transgenic mouse model of Alzheimer's disease

Pietropaolo, Susanna ; Feldon, Joram ; Yee, Benjamin

In: Cognitive, Affective, & Behavioral Neuroscience, 2014, vol. 14, no. 3, p. 996-1008

Myeloid conditional deletion and transgenic models reveal a threshold for the neutrophil survival factor Serpinb1

Burgener, Sabrina S. ; Baumann, Mathias ; Basilico, Paola ; Remold-O'Donnell, Eileen ; Touw, Ivo P. ; Benarafa, Charaf

In: Biological Chemistry, 2016, vol. 397, no. 9, p. 897-905

Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice

Morand, Réjane ; Bouitbir, Jamal ; Felser, Andrea ; Hench, Jürgen ; Handschin, Christoph ; Frank, Stephan ; Krähenbühl, Stephan

In: European Journal of Nutrition, 2014, vol. 53, no. 6, p. 1313-1325

The coactivator PGC-1α regulates skeletal muscle oxidative metabolism independently of the nuclear receptor PPARβ/δ in sedentary mice fed a regular chow diet

Pérez-Schindler, Joaquín ; Svensson, Kristoffer ; Vargas-Fernández, Elyzabeth ; Santos, Gesa ; Wahli, Walter ; Handschin, Christoph

In: Diabetologia, 2014, vol. 57, no. 11, p. 2405-2412

Transcription factor 4 (TCF4) and schizophrenia: integrating the animal and the human perspective

Quednow, Boris ; Brzózka, Magdalena ; Rossner, Moritz

In: Cellular and Molecular Life Sciences, 2014, vol. 71, no. 15, p. 2815-2835

Oedema and fatty degeneration of the soleus and gastrocnemius muscles on MR images in patients with achilles tendon abnormalities

Hoffmann, Adrienne ; Mamisch, Nadja ; Buck, Florian ; Espinosa, Norman ; Pfirrmann, Christian ; Zanetti, Marco

In: European Radiology, 2011, vol. 21, no. 9, p. 1996-2003