In: Current opinion in genetics & development, 2021, vol. 71, p. 39-47
DNA breaks may arise accidentally in vegetative cells or in a programmed manner in meiosis. The usage of a DNA template makes homologous recombination potentially error-free, however, recombination is not always accurate. Cells possess a remarkable capacity to tailor processing of recombination intermediates to fulfill a particular need. Vegetatively growing cells aim to maintain genome...
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In: BioEnergy Research, 2015, vol. 8, no. 1, p. 259-269
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In: Nature Communications, 2020, vol. 11, no. 1, p. 1–9
Recent findings of new Higgs modes in unconventional superconductors require a classification and characterization of the modes allowed by nontrivial gap symmetry. Here we develop a theory for a tailored nonequilibrium quantum quench to excite all possible oscillation symmetries of a superconducting condensate. We show that both a finite momentum transfer and quench symmetry allow for an...
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In: Physical Review B, 2019, vol. 100, no. 7, p. 075152
Spatially inhomogeneous electronic states are expected to be key ingredients for the emergence of superconducting phases in quantum materials hosting charge-density waves (CDWs). Prototypical materials are transitionmetal dichalcogenides (TMDCs) and among them, 1T-TiSe2 exhibiting intertwined CDW and superconducting states under Cu intercalation, pressure, or electrical gating. Although it...
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In: Molecular Cell, 2017, vol. 68, no. 2, p. 414-430.e8
To ensure the completion of DNA replication and maintenance of genome integrity, DNA repair factors protect stalled replication forks upon replication stress. Previous studies have identified a critical role for the tumor suppressors BRCA1 and BRCA2 in preventing the degradation of nascent DNA by the MRE11 nuclease after replication stress. Here we show that depletion of SMARCAL1, a...
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In: Chromosoma, 2018, vol. 127, no. 2 (June), p. 187–214
DNA double-strand breaks arise accidentally upon exposure of DNA to radiation, chemicals or result from faulty DNA metabolic processes. DNA breaks can also be introduced in a programmed manner, such as during the maturation of the immune system, meiosis or cancer chemo- or radiotherapy. Cells have developed a variety of repair pathways, which are fine-tuned to the specific needs of a cell....
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In: Skeletal Radiology, 2014, vol. 43, no. 8, p. 1053-1056
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In: Physical Review B, 2019, vol. 99, no. 15, p. 155103
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In: Molecular Ecology, 2019, vol. 28, no. 6, p. 1263–1282
Chromosomal inversions, structural mutations that reverse a segment of a chromosome, cause suppression of recombination in the heterozygous state. Several studies have shown that inversion polymorphisms can form clines or fluctuate predictably in frequency over seasonal time spans. These observations prompted the hypothesis that chromosomal rearrangements might be subject to spatially and/or ...
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In: Genes and development, 2018, vol. 32, no. 3-4, p. 283-296
Meiotic crossover formation requires the stabilization of early recombination intermediates by a set of proteins and occurs within the environment of the chromosome axis, a structure important for the regulation of meiotic recombination events. The molecular mechanisms underlying and connecting crossover recombination and axis localization are elusive. Here, we identified the ZZS...
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