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Cobicistat versus ritonavir boosting and differences in the drug-drug interaction profiles with co-medications

Marzolini, Catia ; Gibbons, Sara ; Khoo, Saye ; Back, David

In: Journal of Antimicrobial Chemotherapy, 2016, vol. 71, no. 7, p. 1755-1758

Effect of renal clearance and continuous renal replacement therapy on appropriateness of recommended meropenem dosing regimens in critically ill patients with susceptible life-threatening infections

Burger, Raphaël ; Guidi, Monia ; Calpini, Valérie ; Lamoth, Frédéric ; Decosterd, Laurent ; Robatel, Corinne ; Buclin, Thierry ; Csajka, Chantal ; Marchetti, Oscar

In: Journal of Antimicrobial Chemotherapy, 2018, vol. 73, no. 12, p. 3413-3422

Differential cellular expression of organic anion transporting peptides OATP1A2 and OATP2B1 in the human retina and brain: implications for carrier-mediated transport of neuropeptides and neurosteriods in the CNS

Gao, Bo ; Vavricka, Stephan ; Meier, Peter ; Stieger, Bruno

In: Pflügers Archiv - European Journal of Physiology, 2015, vol. 467, no. 7, p. 1481-1493

Long-term In Vivo Calcium Imaging of Astrocytes Reveals Distinct Cellular Compartment Responses to Sensory Stimulation

Stobart, Jillian L. ; Ferrari, Kim David ; Barrett, Matthew J P. ; Stobart, Michael J. ; Looser, Zoe J. ; Saab, Aiman S. ; Weber, Bruno

In: Cerebral Cortex, 2018, vol. 28, no. 1, p. 184-198

Release and Decay Kinetics of Copeptin vs AVP in Response to Osmotic Alterations in Healthy Volunteers

Fenske, Wiebke K. ; Schnyder, Ingeborg ; Koch, Gilbert ; Walti, Carla ; Pfister, Marc ; Kopp, Peter ; Fassnacht, Martin ; Strauss, Konrad ; Christ-Crain, Mirjam

In: The Journal of Clinical Endocrinology & Metabolism, 2017, vol. 103, no. 2, p. 505-513

Using dried blood spots to facilitate therapeutic drug monitoring of antiretroviral drugs in resource-poor regions

Duthaler, Urs ; Berger, Benjamin ; Erb, Stefan ; Battegay, Manuel ; Letang, Emili ; Gaugler, Stefan ; Natamatungiro, Alex ; Mnzava, Dorcas ; Donzelli, Massimiliano ; Krähenbühl, Stephan ; Haschke, Manuel

In: Journal of Antimicrobial Chemotherapy, 2018, vol. 73, no. 10, p. 2729-2737

Pharmacokinetics and Concentration-Effect Relationship of Oral LSD in Humans

Dolder, Patrick C. ; Schmid, Yasmin ; Haschke, Manuel ; Rentsch, Katharina M. ; Liechti, Matthias E.

In: International Journal of Neuropsychopharmacology, 2016, vol. 19, no. 1, p. -

Population pharmacokinetic analysis of elvitegravir and cobicistat in HIV-1-infected individuals

Barceló, Catalina ; Gaspar, Frédéric ; Aouri, Manel ; Panchaud, Alice ; Rotger, Margalida ; Guidi, Monia ; Cavassini, Matthias ; Buclin, Thierry ; Decosterd, Laurent A. ; Csajka, Chantal ; Aubert, V. ; Battegay, M. ; Bernasconi, E. ; Böni, J. ; Braun, DL ; Bucher, HC ; Burton-Jeangros, C. ; Calmy, A. ; Cavassini, M. ; Dollenmaier, G. ; Egger, M. ; Elzi, L. ; Fehr, J. ; Fellay, J. ; Furrer, H. ; Fux, CA ; Gorgievski, M. ; Günthard, H. ; Haerry, D. ; Hasse, B. ; Hirsch, HH ; Hoffmann, M. ; Hösli, I. ; Kahlert, C. ; Kaiser, L. ; Keiser, O. ; Klimkait, T. ; Kouyos, R. ; Kovari, H. ; Ledergerber, B. ; Martinetti, G. ; Martinez de Tejada, B. ; Marzolini, C. ; Metzner, K. ; Müller, N. ; Nadal, D. ; Nicca, D. ; Pantaleo, G. ; Rauch, A. ; Regenass, S. ; Rudin, C. ; Schöni-Affolter, F. ; Schmid, P. ; Speck, R. ; Stöckle, M. ; Tarr, P. ; Trkola, A. ; Vernazza, P. ; Weber, R. ; Yerly, S. ; Aubert, V. ; Battegay, M. ; Bernasconi, E. ; Böni, J. ; Braun, DL ; Bucher, HC ; Burton-Jeangros, C. ; Calmy, A. ; Cavassini, M. ; Dollenmaier, G. ; Egger, M. ; Elzi, L. ; Fehr, J. ; Fellay, J. ; Furrer, H. ; Fux, CA ; Gorgievski, M. ; Günthard, H. ; Haerry, D. ; Hasse, B. ; Hirsch, HH ; Hoffmann, M. ; Hösli, I. ; Kahlert, C. ; Kaiser, L. ; Keiser, O. ; Klimkait, T. ; Kouyos, R. ; Kovari, H. ; Ledergerber, B. ; Martinetti, G. ; Martinez de Tejada, B. ; Marzolini, C. ; Metzner, K. ; Müller, N. ; Nadal, D. ; Nicca, D. ; Pantaleo, G. ; Rauch, A. ; Regenass, S. ; Rudin, C. ; Schöni-Affolter, F. ; Schmid, P. ; Speck, R. ; Stöckle, M. ; Tarr, P. ; Trkola, A. ; Vernazza, P. ; Weber, R. ; Yerly, S.

In: Journal of Antimicrobial Chemotherapy, 2016, vol. 71, no. 7, p. 1933-1942

Proteasomal and lysosomal clearance of faulty secretory proteins : ER-associated degradation (ERAD) and ER-to-lysosome-associated degradation (ERLAD) pathways

Fregno, Ilaria ; Molinari, Maurizio

In: Critical reviews in biochemistry and molecular biology, 2019, vol. 54, no. 2, p. 153-163

About 40% of the eukaryotic cell’s proteins are inserted co- or post-translationally in the endoplasmic reticulum (ER), where they attain the native structure under the assistance of resident molecular chaperones and folding enzymes. Subsequently, these proteins are secreted from cells or are transported to their sites of function at the plasma membrane or in organelles of the secretory and ...

Subcellular distribution of FTY720 and FTY720-phosphate in immune cells - another aspect of Fingolimod action relevant for therapeutic application

Schröder, Matthias ; Arlt, Olga ; Schmidt, Helmut ; Huwiler, Andrea ; Angioni, Carlo ; Pfeilschifter, Josef M. ; Schwiebs, Anja ; Radeke, Heinfried H.

In: Biological Chemistry, 2015, vol. 396, no. 6-7, p. 795-802