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Université de Fribourg

Dimercaptosuccinic acid in combination with carbapenems against isogenic strains of Escherichia coli producing or not producing a metallo-β-lactamase in vitro and in murine peritonitis

Cheminet, G. ; de Lastours, V. ; Poirel, Laurent ; Chau, F. ; Peoc’h, K. ; Massias, L. ; Fantin, B. ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2020, vol. 75, no. 12, p. 3593–3600

Background: Carbapenemase-producing Enterobacterales represent a major therapeutic challenge. MBLs, requiring zinc at their catalytic site, could be inhibited by meso-dimercaptosuccinic acid (DMSA), a heavy metal chelator already widely used for treating lead intoxication.Objectives: To evaluate the activity of carbapenems alone or combined with DMSA against MBL-producing Escherichia coli in...

Université de Fribourg

Mechanism of cystathionine-β-synthase inhibition by disulfiram : The role of bis(N,N-diethyldithiocarbamate)-copper(II)

Zuhra, Karim ; Panagaki, Theodora ; B.Randi, Elisa ; Augsburger, Fiona ; Blondel, Marc ; Friocourt, Gaelle ; Herault, Yann ; Szabo, Csaba

In: Biochemical Pharmacology, 2020, vol. 182, p. 114267

Background: Hydrogen sulfide (H2S) is an endogenous mammalian gasotransmitter. Cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE) and 3- mercaptopyruvate sulfurtransferase (3-MST) are the principal enzymes responsible for its biogenesis. A recent yeast screen suggested that disulfiram (a well-known inhibitor of aldehyde dehydrogenase and a clinically used drug in the treatment of...

Université de Fribourg

Nature of native atomic defects in ${\mathrm{ZrTe}}_{5}$ and their impact on the low-energy electronic structure

Salzmann, Björn ; Pulkkinen, Aki ; Hildebrand, Baptiste ; Jaouen, Thomas ; Zhang, S. N. ; Martino, E. ; Li, Q. ; Gu, G. ; Berger, Helmuth ; Yazyev, O. V. ; Akrap, Ana ; Monney, Claude

In: Physical Review Materials, 2020, vol. 4, no. 11, p. 114201

Over the past decades, investigations of the anomalous low-energy electronic properties of ZrTe5 have reached a wide array of conclusions. An open question is the growth method's impact on the stoichiometry of ZrTe5 samples, especially given the very small density of states near its chemical potential. Here we report on high- resolution scanning tunneling microscopy and spectroscopy...

Université de Fribourg

Misfit layer compounds: a platform for heavily doped 2D transition metal dichalcogenides

Leriche, Raphaël T. ; Palacio‐Morales, Alexandra ; Campetella, Marco ; Tresca, Cesare ; Sasaki, Shunsuke ; Brun, Christophe ; Debontridder, François ; David, Pascal ; Arfaoui, Imad ; Šofranko, Ondrej ; Samuely, Tomas ; Kremer, Geoffroy ; Monney, Claude ; Jaouen, Thomas ; Cario, Laurent ; Calandra, Matteo ; Cren, Tristan

In: Advanced Functional Materials, 2020, p. 2007706

Transition metal dichalcogenides (TMDs) display a rich variety of instabilities such as spin and charge orders, Ising superconductivity, and topological properties. Their physical properties can be controlled by doping in electric double‐layer field‐effect transistors (FET). However, for the case of single layer NbSe2, FET doping is limited to ≈1 × 1014 cm−2, while a somewhat larger...

Université de Fribourg

Oriented basement membrane fibrils provide a memory for F-actin planar polarization via the Dystrophin-Dystroglycan complex during tissue elongation

Cerqueira Campos, Fabiana ; Dennis, Cynthia ; Alégot, Hervé ; Fritsch, Cornelia ; Isabella, Adam ; Pouchin, Pierre ; Bardot, Olivier ; Horne-Badovinac, Sally ; Mirouse, Vincent

In: Development, 2020, vol. 147, no. 7, p. dev186957

How extracellular matrix contributes to tissue morphogenesis is still an open question. In the Drosophila ovarian follicle, it has been proposed that after Fat2-dependent planar polarization of the follicle cell basal domain, oriented basement membrane (BM) fibrils and F-actin stress fibers constrain follicle growth, promoting its axial elongation. However, the relationship between BM fibrils...