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Università della Svizzera italiana

Impact of COVID-19 on the thyroid gland : an update

Scappaticcio, Lorenzo ; Pitoia, Fabián ; Esposito, Katherine ; Piccardo, Arnoldo ; Trimboli, Pierpaolo

In: Reviews in Endocrine and Metabolic Disorders, 2020, p. 13

Coronavirus disease 2019 (COVID-19) is the pandemic of the new millennium. COVID-19 can cause both pulmonary and systemic inflammation, potentially determining multi-organ dysfunction. Data on the relationship between COVID-19 and thyroid have been emerging, and rapidly increasing since March 2020. The thyroid gland and the virus infection with its associated inflammatory-immune responses are...

Université de Fribourg

Characterising Chordal Contact : Bo-VPG Graphs

Bonomo, Flavia ; Mazzoleni, Maria Pia ; Rean, Mariano Leonardo ; Ries, Bernard

In: Lecture Notes in Computer Science, 2018, vol. 10856, p. 89-100

A graph G is a Bo- VPG graph if it is the vertex intersection graph of horizontal and vertical paths on a grid. A graph G is a contact Bo- VPG graph if the vertices can be represented by interiorly disjoint horizontal or vertical paths on a grid and two vertices are adjacent if and only if the corresponding paths touch. In this paper, we present a minimal forbidden induced subgraph...

Université de Fribourg

The metalloprotease ADAMTS4 generates N-truncated Aβ4–x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer’s disease

Walter, Susanne ; Jumpertz, Thorsten ; Hüttenrauch, Melanie ; Ogorek, Isabella ; Gerber, Hermeto ; Storck, Steffen E. ; Zampar, Silvia ; Dimitrov, Mitko ; Lehmann, Sandra ; Lepka, Klaudia ; Berndt, Carsten ; Wiltfang, Jens ; Becker-Pauly, Christoph ; Beher, Dirk ; Pietrzik, Claus U. ; Fraering, Patrick C. ; Wirths, Oliver

In: Acta Neuropathologica, 2019, vol. 137, no. 2, p. 239–257

Brain accumulation and aggregation of amyloid-β (Aβ) peptides is a critical step in the pathogenesis of Alzheimer’s disease (AD). Full-length Aβ peptides (mainly Aβ1–40 and Aβ1–42) are produced through sequential proteolytic cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. However, studies of autopsy brain samples from AD patients have demonstrated that a...