In: Applied Microbiology and Biotechnology, 2015, vol. 99, no. 20, p. 8475-8486
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In: Biology of Reproduction, 2018, vol. 99, no. 3, p. 600-610
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In: The Journal of Physical Chemistry B, 2020, vol. 124, no. 5, p. 828–839
Ethanolamine plasmalogen (EtnPLA) is a conical-shaped ether lipid and an essential component of neurological membranes. Low stability against oxidation limits its study in experiments. The concentration of EtnPLA in the bilayer varies depending on cell type and disease progression. Here we report on mixed bilayers of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1-(1Z-...
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In: Discrete Applied Mathematics, 2011, vol. 159, no. 17, p. 1971-1995
Strongly perfect graphs have been studied by several authors (e.g. Berge and Duchet (1984) [1], Ravindra (1984) [12] and Wang (2006) [14]). In a series of two papers, the current paper being the first one, we investigate a fractional relaxation of strong perfection. Motivated by a wireless networking problem, we consider claw-free graphs that are fractionally strongly perfect in the complement....
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In: Plos pathogens, 2013, vol. 9, no. 11, p. e1003776
The mechanisms by which human immunodeficiency virus type 1 (HIV-1) crosses mucosal surfaces to establish infection are unknown. Acidic genital secretions of HIV-1-infected women contain HIV-1 likely coated by antibody. We found that the combination of acidic pH and Env- specific IgG, including that from cervicovaginal and seminal fluids of HIV-1-infected individuals, augmented transcytosis...
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In: Plos pathogens, 2013, vol. 9, no. 2, p. e1003157
Dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) are life-threatening complications following infection with one of the four serotypes of dengue virus (DENV). At present, no vaccine or antiviral therapies are available against dengue. Here, we characterized a panel of eight human or mouse-human chimeric monoclonal antibodies (MAbs) and their modified variants lacking effector...
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In: Plos pathogens, 2013, vol. 9, no. 1, p. e1003130
An understanding of the immunological footprint of Mycobacterium tuberculosis (MTB) CD4 T cell recognition is still incomplete. Here we report that human Th1 cells specific for MTB are largely contained in a CXCR3+CCR6+ memory subset and highly focused on three broadly immunodominant antigenic islands, all related to bacterial secretion systems. Our results refute the notion that secreted...
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In: Plos one, 2011, vol. 6, no. 3, p. e18207
Neutralizing antibodies have been shown to protect macaques against SHIV challenge. However, genetically diverse HIV-1 clades have evolved, and a key question left unanswered is whether neutralizing antibodies can confer cross-clade protection in vivo. The novel human monoclonal antibody HGN194 was isolated from an individual infected with an HIV-1 clade AG recombinant circulating recombinant...
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In: Pacific Journal of Mathematics, 2019, vol. 298, no. 2, p. 267–284
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In: Frontiers in Microbiology, 2019, vol. 10, p. -
Mycoplasmas are the smallest free-living organisms and cause a number of economically important diseases affecting humans, animals, insects, and plants. Here, we demonstrate that highly virulent Mycoplasma mycoides subspecies capri (Mmc) can be fully attenuated via targeted deletion of non-essential genes encoding, among others, potential virulence traits. Five genomic regions, representing...
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