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Brain natriuretic peptide is able to stimulate cardiac progenitor cell proliferation and differentiation in murine hearts after birth

Bielmann, Christelle ; Rignault-Clerc, Stéphanie ; Liaudet, Lucas ; Li, Feng ; Kunieda, Tetsuo ; Sogawa, Chizuru ; Zehnder, Tamara ; Waeber, Bernard ; Feihl, François ; Rosenblatt-Velin, Nathalie

In: Basic Research in Cardiology, 2015, vol. 110, no. 1, p. 1-17

N -methyl pyrrolidone (NMP) inhibits lipopolysaccharide-induced inflammation by suppressing NF-κB signaling

Ghayor, Chafik ; Gjoksi, Bebeka ; Siegenthaler, Barbara ; Weber, Franz

In: Inflammation Research, 2015, vol. 64, no. 7, p. 527-536

Sterile-filtered saliva is a strong inducer of IL-6 and IL-8 in oral fibroblasts

Cvikl, Barbara ; Lussi, Adrian ; Moritz, Andreas ; Sculean, Anton ; Gruber, Reinhard

In: Clinical Oral Investigations, 2015, vol. 19, no. 2, p. 385-399

Experimental ex vivo lung perfusion with sevoflurane: effects on damaged donor lung grafts

Wang, Xingyu ; Parapanov, Roumen ; Francioli, Cyril ; Perentes, Jean Yannis ; Letovanec, Igor ; Gonzalez, Michel ; Kern, Christian ; Ris, Hans-Beat ; Piquilloud, Lise ; Marcucci, Carlo ; Krueger, Thorsten ; Liaudet, Lucas ; Gronchi, Fabrizio

In: Interactive CardioVascular and Thoracic Surgery, 2018, vol. 26, no. 6, p. 977-984

Effects of the poly(ADP-ribose) polymerase inhibitor olaparib in cerulein-induced pancreatitis

Ahmad, Akbar ; Haas De Mello, Aline ; Szczesny, Bartosz ; Törö, Gábor ; Marcatti, Michela ; Druzhyna, Nadiya ; Liaudet, Lucas ; Tarantini, Stefano ; Salomao, Reinaldo ; Garcia Soriano, Francisco ; Szabo, Csaba

In: Shock, 2020, vol. 53, no. 5, p. 653–665

Objective: Activation of the constitutive nuclear and mitochondrial enzyme poly (ADP- ribose) polymerase (PARP) has been implicated in the pathogenesis of cell dysfunction, inflammation, and organ failure in various forms of critical illness. The objective of our study was to evaluate the efficacy and safety of the clinically approved PARP inhibitor olaparib in an experimental model of...

Blocking mineralocorticoid receptor with spironolactone may have a wide range of therapeutic actions in severe COVID-19 disease

Liaudet, Lucas ; Szabo, Csaba

In: Critical Care, 2020, vol. 24, no. 1, p. 318

A novel interaction between the TLR7 and a colchicine derivative revealed through a computational and experimental study

Gentile, Francesco ; Deriu, Marco A. ; Barakat, Khaled ; Danani, Andrea ; Tuszynski, Jack

In: Pharmaceuticals, 2018, vol. 11, no. 1, p. 22

The Toll-Like Receptor 7 (TLR7) is an endosomal membrane receptor involved in the innate immune system response. Its best-known small molecule activators are imidazoquinoline derivatives such as imiquimod (R-837) and resiquimod (R-848). Recently, an interaction between R-837 and the colchicine binding site of tubulin was reported. To investigate the possibility of an interaction between...

Effect of 3-mercaptopyruvate sulfurtransferase deficiency on the development of multiorgan failure, inflammation, and wound healing in mice subjected to burn injury

Ahmad, Akbar ; Druzhyna, Nadiya ; Szabo, Csaba

In: Journal of Burn Care & Research, 2019, vol. 40, no. 2, p. 148–156

The gaseous transmitter hydrogen sulfide (H2S) has been implicated in various forms of critical illness. Here, we have compared the outcome of scald burn injury in wild- type mice and in mice deficient in 3-mercaptopyruvate sulfurtransferase (3-MST), a mammalian H2S-generating enzyme. Outcome variables included indices of organ injury, clinical chemistry parameters, and plasma levels of...

Hypoxia enhances endothelial intercellular adhesion molecule 1 protein level through upregulation of arginase type II and mitochondrial oxidative stress

Liang, Xiujie ; Arullampalam, Prakash ; Yang, Zhihong ; Ming, Xiu-Fen

In: Frontiers in Physiology, 2019, vol. 10, p. -

Hypoxia plays a crucial role in the pathogenesis of cardiovascular diseases. Mitochondrial enzyme arginase type II (Arg-II) is reported to lead to endothelial dysfunction and enhance the expression of endothelial inflammatory adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). In this study, we investigate the role of Arg-II in...

Macrophage death following influenza vaccination initiates the inflammatory response that promotes dendritic cell function in the draining lymph node

Chatziandreou, Nikolaos ; Farsakoglu, Yagmur ; Palomino-Segura, Miguel ; D’Antuono, Rocco ; Pizzagalli, Diego Ulisse ; Sallusto, Federica ; Lukacs-Kornek, Veronika ; Uguccioni, Mariagrazia ; Corti, Davide ; Turley, Shannon J. ; Lanzavecchia, Antonio ; Carroll, Michael C. ; Gonzalez, Santiago F.

In: Cell reports, 2017, vol. 18, no. 10, p. 2427-2440

The mechanism by which inflammation influences the adaptive response to vaccines is not fully understood. Here, we examine the role of lymph node macrophages (LNMs) in the induction of the cytokine storm triggered by inactivated influenza virus vaccine. Following vaccination, LNMs undergo inflammasome-independent necrosis-like death that is reliant on MyD88 and Toll-like receptor 7 (TLR7)...