Affiner les résultats

Type de document

Collection spécifique

Langue

Université de Fribourg

Tissue-specific isoforms of the single C. elegans Ryanodine receptor gene unc-68 control specific functions

Marques, Filipe ; Thapliyal, Saurabh ; Javer, Avelino ; Shrestha, Priyanka ; Brown, André E. X. ; Glauser, Dominique A.

In: PLOS Genetics, 2020, vol. 16, no. 10, p. e1009102

Ryanodine receptors (RyR) are essential regulators of cellular calcium homeostasis and signaling. Vertebrate genomes contain multiple RyR gene isoforms, expressed in different tissues and executing different functions. In contrast, invertebrate genomes contain a single RyR-encoding gene and it has long been proposed that different transcripts generated by alternative splicing may diversify...

Università della Svizzera italiana

The Tim-3-Galectin-9 Pathway and Its Regulatory Mechanisms in Human Breast Cancer

Yasinska, Inna M. ; Sakhnevych, Svetlana S. ; Pavlova, Ludmila ; Hansen Selnø, Anette Teo ; Teuscher Abeleira, Ana Maria ; Benlaouer, Ouafa ; Gonçalves Silva, Isabel ; Mosimann, Marianne ; Varani, Luca ; Bardelli, Marco ; Hussain, Rohanah ; Siligardi, Giuliano ; Cholewa, Dietmar ; Berger, Steffen M. ; Gibbs, Bernhard F. ; Ushkaryov, Yuri A. ; Fasler-Kan, Elizaveta ; Klenova, Elena ; Sumbayev, Vadim V.

In: Frontiers in immunology, 2019, vol. 10, p. 1594

Human cancer cells operate a variety of effective molecular and signaling mechanisms which allow them to escape host immune surveillance and thus progress the disease. We have recently reported that the immune receptor Tim-3 and its natural ligand galectin-9 are involved in the immune escape of human acute myeloid leukemia (AML) cells. These cells use the neuronal receptor latrophilin 1...

Université de Fribourg

Reducing the Clique and Chromatic Number via Edge Contractions and Vertex Deletions

Paulusma, Daniël ; Picouleau, Christophe ; Ries, Bernard

In: Lecture Notes in Computer Science, 2016, vol. 9849, p. 38-49

We consider the following problem: can a certain graph parameter of some given graph G be reduced by at least d, for some integer d, via at most k graph operations from some specified set S, for some given integer k? As graph parameters we take the chromatic number and the clique number. We let the set S consist of either an edge contraction or a vertex deletion. As all these problems are...

Università della Svizzera italiana

Influenza hemagglutinin membrane anchor

Benton, Donald J. ; Nans, Andrea ; Calder, Lesley J. ; Turner, Jack ; Neu, Ursula ; Lin, Yi Pu ; Ketelaars, Esther ; Kallewaard, Nicole L. ; Corti, Davide ; Lanzavecchia, Antonio ; Gamblin, Steven J. ; Rosenthal, Peter B. ; Skehel, John J.

In: Proceedings of the national academy of sciences of the United States of America, 2018, vol. 115, no. 40, p. 10112-10117

Viruses with membranes fuse them with cellular membranes, to transfer their genomes into cells at the beginning of infection. For Influenza virus, the membrane glycoprotein involved in fusion is the hemagglutinin (HA), the 3D structure of which is known from X-ray crystallographic studies. The soluble ectodomain fragments used in these studies lacked the “membrane anchor” portion of the...

Université de Fribourg

Remote sensing of cropping practice in Northern Italy using time-series from Sentinel-2

Ottosen, Thor-Bjørn ; Lommen, Suzanne T.E. ; Skjøth, Carsten Ambelas

In: Computers and Electronics in Agriculture, 2019, vol. 157, p. 232–238

Maps of cropping practice, including the level of weed infestation, are useful planning tools e.g. for the assessment of the environmental impact of the crops, and Northern Italy is an important example due to the large and diverse agricultural production and the high weed infestation. Sentinel-2A is a new satellite with a high spatial and temporal resolution which potentially allows the...

Consortium of Swiss Academic Libraries

Multimodality cardiac imaging

Gaemperli, Oliver ; Kaufmann, Philipp

In: Journal of Nuclear Cardiology, 2010, vol. 17, no. 1, p. 4-7

Consortium of Swiss Academic Libraries

Cell cycle regulation by the B-Myb transcription factor

Joaquin, M. ; Watson, R.

In: Cellular and Molecular Life Sciences CMLS, 2003, vol. 60, no. 11, p. 2389-2401