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Boucher-Neuhäuser syndrome: cerebellar degeneration, chorioretinal dystrophy and hypogonadotropic hypogonadism: two novel cases and a review of 40 cases from the literature

Tarnutzer, A. ; Gerth-Kahlert, C. ; Timmann, D. ; Chang, D. ; Harmuth, F. ; Bauer, P. ; Straumann, D. ; Synofzik, M.

In: Journal of Neurology, 2015, vol. 262, no. 1, p. 194-202

Emergence of colistin-resistant Gram-negative Enterobacterales in the gut of patients receiving oral colistin and neomycin decontamination

Lastours, Victoire de ; Poirel, Laurent ; Huttner, Benedikt ; Harbarth, Stephan ; Denamur, Erick ; Nordmann, Patrice

In: Journal of Infection, 2020, vol. 80, no. 5, p. 578–606

Dimercaptosuccinic acid in combination with carbapenems against isogenic strains of Escherichia coli producing or not producing a metallo-β-lactamase in vitro and in murine peritonitis

Cheminet, G. ; de Lastours, V. ; Poirel, Laurent ; Chau, F. ; Peoc’h, K. ; Massias, L. ; Fantin, B. ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2020, vol. 75, no. 12, p. 3593–3600

Background: Carbapenemase-producing Enterobacterales represent a major therapeutic challenge. MBLs, requiring zinc at their catalytic site, could be inhibited by meso-dimercaptosuccinic acid (DMSA), a heavy metal chelator already widely used for treating lead intoxication.Objectives: To evaluate the activity of carbapenems alone or combined with DMSA against MBL-producing Escherichia coli in...

The inoculum effect of Escherichia coli expressing mcr-1 or not on colistin activity in a murine model of peritonitis

Fantin, B. ; Poujade, J. ; Grégoire, N. ; Chau, F. ; Roujansky, A. ; Kieffer, Nicolas ; Berleur, M. ; Couet, W. ; Nordmann, Patrice

In: Clinical Microbiology and Infection, 2019, vol. 25, no. 12, p. 1563.e5-1563.e8

Colistin often remains the last resort antibiotic active against carbapenemase- producing Enterobacteriaceae. However, while in vitro inoculum effect has been reported, therapeutic relevance of this phenomenon remains questioned.Methods: Ten E. coli strains were used that included the wild-type CFT073 and its transconjugant CFT073-MCR-1 and eight susceptible clinical isolates. Mice with ...

mcr-9, An inducible gene encoding an acquired phosphoethanolamine transferase in Escherichia coli, and its origin

Kieffer, Nicolas ; Royer, b Guilhem ; Decousser, Jean-Winoc ; Bourrel, Anne-Sophie ; Palmieri, Mattia ; Ortiz De La Rosa, Jose-Manuel ; Jacquier, Hervé ; Denamur, Erick ; Nordmann, Patrice ; Poirel, Laurent

In: Antimicrobial Agents and Chemotherapy, 2019, vol. 63, no. 9, p. -

The plasmid-located mcr-9 gene, encoding a putative phosphoethanolamine transferase, was identified in a colistin-resistant human fecal Escherichia coli strain belonging to a very rare phylogroup, the D-ST69-O15:H6 clone. This MCR-9 protein shares 33% to 65% identity with the other plasmid-encoded MCR-type enzymes identified (MCR-1 to -8) that have been found as sources of acquired resistance...

Altering the temporal regulation of one transcription factor drives evolutionary trade-offs between head sensory organs

Ramaekers, Ariane ; Claeys, Annelies ; Kapun, Martin ; Mouchel-Vielh, Emmanuèle ; Potier, Delphine ; Weinberger, Simon ; Grillenzoni, Nicola ; Dardalhon-Cuménal, Delphine ; Yan, Jiekun ; Wolf, Reinhard ; Flatt, Thomas ; Buchner, Erich ; Hassan, Bassem A.

In: Developmental Cell, 2019, vol. 50, no. 6, p. 780-792.e7

Size trade-offs of visual versus olfactory organs is a pervasive feature of animal evolution. This could result from genetic or functional constraints. We demonstrate that head sensory organ size trade-offs in Drosophila are genetically encoded and arise through differential subdivision of the head primordium into visual versus non- visual fields. We discover that changes in the temporal...

Colistin resistance in Parisian inpatient faecal Escherichia coli as the result of two distinct evolutionary pathways

Bourrel, Anne Sophie ; Poirel, Laurent ; Royer, Guilhem ; Darty, Mélanie ; Vuillemin, Xavier ; Kieffer, Nicolas ; Clermont, Olivier ; Denamur, Erick ; Nordmann, Patrice ; Decousser, Jean-Winoc ; The IAME Resistance Group

In: Journal of Antimicrobial Chemotherapy, 2019, vol. 74, no. 6, p. 1521–1530

Beyond plasmid-encoded resistance (mcr genes) prevalence in strain collections, large epidemiological studies to estimate the human burden of colistin-resistant Escherichia coli gut carriage are lacking.Objectives: To evaluate the prevalence of colistin-resistant E. coli carriage in inpatients and decipher the molecular support of resistance and the genetic background of the strains.Methods:...

Functional characterization of the novel sequence variant p.S304R in the hinge region of TSHR in a congenital hypothyroidism patients and analogy with other formerly known mutations of this gene portion

Cerqueira, Taise Lima Oliveira ; Carré, Aurore ; Chevrier, Lucie ; Szinnai, Gabor ; Tron, Elodie ; Léger, Juliane ; Cabrol, Sylvie ; Queinnec, Chrystelle ; De Roux, Nicolas ; Castanet, Mireille ; Polak, Michel ; Ramos, Helton Estrela

In: Journal of Pediatric Endocrinology and Metabolism, 2015, vol. 28, no. 7-8, p. 777-784

Economic evaluation of procalcitonin-guided antibiotic therapy in acute respiratory infections: a US health system perspective

Schuetz, Philipp ; Balk, Robert ; Briel, Matthias ; Kutz, Alexander ; Christ-Crain, Mirjam ; Stolz, Daiana ; Bouadma, Lila ; Wolff, Michel ; Kristoffersen, Kristina B. ; Wei, Long ; Burkhardt, Olaf ; Welte, Tobias ; Schroeder, Stefan ; Nobre, Vandack ; Tamm, Michael ; Bhatnagar, Neera ; Bucher, Heiner C. ; Luyt, Charles-Edouard ; Chastre, Jean ; Tubach, Florence ; Mueller, Beat ; Lacey, Michael J. ; Ohsfeldt, Robert L. ; Scheibling, Cara M. ; Schneider, John E.

In: Clinical Chemistry and Laboratory Medicine (CCLM), 2015, vol. 53, no. 4, p. 583-592

Comparison between B·R·A·H·M·S PCT direct, a new sensitive point-of-care testing device for rapid quantification of procalcitonin in emergency department patients and established reference methods - a prospective multinational trial

Kutz, Alexander ; Hausfater, Pierre ; Oppert, Michael ; Alan, Murat ; Grolimund, Eva ; Gast, Claire ; Alonso, Christine ; Wissmann, Christoph ; Kuehn, Christian ; Bernard, Maguy ; Huber, Andreas ; Mueller, Beat ; Schuetz, Philipp

In: Clinical Chemistry and Laboratory Medicine (CCLM), 2016, vol. 54, no. 4, p. 577-584