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Université de Fribourg

Cell cycle constraints and environmental control of local DNA hypomethylation in α-proteobacteria

Ardissone, Silvia ; Redder, Peter ; Russo, Giancarlo ; Frandi, Antonio ; Fumeaux, Coralie ; Patrignani, Andrea ; Schlapbach, Ralph ; Falquet, Laurent ; Viollier, Patrick H.

In: PLOS Genetics, 2016, vol. 12, no. 12, p. e1006499

Heritable DNA methylation imprints are ubiquitous and underlie genetic variability from bacteria to humans. In microbial genomes, DNA methylation has been implicated in gene transcription, DNA replication and repair, nucleoid segregation, transposition and virulence of pathogenic strains. Despite the importance of local (hypo)methylation at specific loci, how and when these patterns are...

Université de Fribourg

Hook length of the bacterial flagellum is optimized for maximal stability of the flagellar bundle

Spöring, Imke ; Martinez, Vincent A. ; Hotz, Christian ; Schwarz-Linek, Jana ; Grady, Keara L. ; Nava-Sedeño, Josué M. ; Vissers, Teun ; Singer, Hanna M. ; Rohde, Manfred ; Bourquin, Carole ; Hatzikirou, Haralampos ; Poon, Wilson C. K. ; Dufour, Yann S. ; Erhardt, Marc

In: PLOS Biology, 2018, vol. 16, no. 9, p. e2006989

Most bacteria swim in liquid environments by rotating one or several flagella. The long external filament of the flagellum is connected to a membrane-embedded basal body by a flexible universal joint, the hook, which allows the transmission of motor torque to the filament. The length of the hook is controlled on a nanometer scale by a sophisticated molecular ruler mechanism. However, why its...

Université de Fribourg

An armadillo-domain protein participates in a telomerase interaction network

Dokládal, Ladislav ; Benková, Eva ; Honys, David ; Dup?áková, Nikoleta ; Lee, Lan-Ying ; Gelvin, Stanton B. ; Sýkorová, Eva

In: Plant Molecular Biology, 2018, vol. 97, no. 4, p. 407–420

Key messageArabidopsis and human ARM protein interact with telomerase. Deregulated mRNA levels of DNA repair and ribosomal protein genes in an Arabidopsis arm mutant suggest non-telomeric ARM function. The human homolog ARMC6 interacts with hTRF2.AbstractTelomerase maintains telomeres and has proposed non-telomeric functions. We previously identified interaction of the C- terminal domain of...

Consortium of Swiss Academic Libraries

Chromatin-associated ncRNA activities

Keller, Claudia ; Bühler, Marc

In: Chromosome Research, 2013, vol. 21, no. 6-7, p. 627-641

Consortium of Swiss Academic Libraries

Lack of large-angle TT correlations persists in WMAP and Planck

Copi, Craig J. ; Huterer, Dragan ; Schwarz, Dominik J. ; Starkman, Glenn D.

In: Monthly Notices of the Royal Astronomical Society, 2015, vol. 451, no. 3, p. 2978-2985

Consortium of Swiss Academic Libraries

Large-scale alignments from WMAPand Planck

Copi, Craig J. ; Huterer, Dragan ; Schwarz, Dominik J. ; Starkman, Glenn D.

In: Monthly Notices of the Royal Astronomical Society, 2015, vol. 449, no. 4, p. 3458-3470