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Università della Svizzera italiana

Schwann cells ER-associated degradation contributes to myelin maintenance in adult nerves and limits demyelination in CMT1B mice

Volpi, Vera G. ; Ferri, Cinzia ; Fregno, Ilaria ; Del Carro, Ubaldo ; Bianchi, Francesca ; Scapin, Cristina ; Pettinato, Emanuela ; Solda, Tatiana ; Feltri, M. Laura ; Molinari, Maurizio ; Wrabetz, Lawrence ; D’Antonio, Maurizio

In: PLOS genetics, 2019, vol. 15, no. 4, p. e1008069

In the peripheral nervous system (PNS) myelinating Schwann cells synthesize large amounts of myelin protein zero (P0) glycoprotein, an abundant component of peripheral nerve myelin. In humans, mutations in P0 cause the demyelinating Charcot-Marie-Tooth 1B (CMT1B) neuropathy, one of the most diffused genetic disorders of the PNS. We previously showed that several mutations, such as the...

Université de Fribourg

Injured axons instruct schwann cells to build constricting actin spheres to accelerate axonal disintegration

Vaquié, Adrien ; Sauvain, Alizée ; Duman, Mert ; Nocera, Gianluigi ; Egger, Boris ; Meyenhofer, Felix ; Falquet, Laurent ; Bartesaghi, Luca ; Chrast, Roman ; Lamy, Christophe Maurice ; Bang, Seokyoung ; Lee, Seung-Ryeol ; Jeon, Noo Li ; Ruff, Sophie ; Jacob, Claire

In: Cell Reports, 2019, vol. 27, no. 11, p. 3152-3166.e7

After a peripheral nerve lesion, distal ends of injured axons disintegrate into small fragments that are subsequently cleared by Schwann cells and later by macrophages. Axonal debris clearing is an early step of the repair process that facilitates regeneration. We show here that Schwann cells promote distal cut axon disintegration for timely clearing. By combining cell-based and in vivo...

Consortium of Swiss Academic Libraries

Phosphoinositides and Charcot-Marie-Tooth disease: New keys to old questions

Suter, U.

In: Cellular and Molecular Life Sciences, 2007, vol. 64, no. 24, p. 3261-3265

Consortium of Swiss Academic Libraries

How Histone Deacetylases Control Myelination

Jacob, Claire ; Lebrun-Julien, Frédéric ; Suter, Ueli

In: Molecular Neurobiology, 2011, vol. 44, no. 3, p. 303-312