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Università della Svizzera italiana

Dexamethasone induces changes in osteogenic differentiation of human mesenchymal stromal cells via SOX9 and PPARG, but not RUNX2

Della Bella, Elena ; Buetti-Dinh, Antoine ; Licandro, Ginevra ; Ahmad, Paras ; Basoli, Valentina ; Alini, Mauro ; Stoddart, Martin J.

In: International journal of molecular sciences, 2021, vol. 22, no. 9, p. 16

Despite the huge body of research on osteogenic differentiation and bone tissue engineering, the translation potential of in vitro results still does not match the effort employed. One reason might be that the protocols used for in vitro research have inherent pitfalls. The synthetic glucocorticoid dexamethasone is commonly used in protocols for trilineage differentiation of human bone marrow...

Université de Fribourg

MAcroecological Framework for Invasive Aliens (MAFIA): disentangling large-scale context dependence in biological invasions

Pyšek, Petr ; Bacher, Sven ; Kühn, Ingolf ; Novoa, Ana ; Catford, Jane A. ; Hulme, Philip E. ; Pergl, Jan ; Richardson, David M. ; Wilson, John R. U. ; Blackburn, Tim M.

In: NeoBiota, 2020, vol. 62, p. 407–461

Macroecology is the study of patterns, and the processes that determine those patterns, in the distribution and abundance of organisms at large scales, whether they be spatial (from hundreds of kilometres to global), temporal (from decades to centuries), and organismal (numbers of species or higher taxa). In the context of invasion ecology, macroecological studies include, for example,...

Université de Fribourg

The importance of assessing positive and beneficial impacts of alien species

Vimercati, Giovanni ; Kumschick, Sabrina ; Probert, Anna F. ; Volery, Lara ; Bacher, Sven

In: NeoBiota, 2020, vol. 62, p. 525–545

Extensive literature is available on the diversity and magnitude of impacts that alien species cause on recipient systems. Alien species may decrease or increase attributes of ecosystems (e.g. total biomass or species diversity), thus causing negative and positive environmental impacts. Alien species may also negatively or positively impact attributes linked to local human communities (e.g....

Université de Fribourg

Frameworks used in invasion science: progress and prospects

Wilson, John R.U. ; Bacher, Sven ; Daehler, Curtis C. ; Groom, Quentin J. ; Kumschick, Sabrina ; Lockwood, Julie L. ; Robinson, Tamara B. ; Zengeya, Tsungai A. ; Richardson, David M.

In: NeoBiota, 2020, vol. 62, p. 1–30

Our understanding and management of biological invasions relies on our ability to classify and conceptualise the phenomenon. This need has stimulated the development of a plethora of frameworks, ranging in nature from conceptual to applied. However, most of these frameworks have not been widely tested and their general applicability is unknown. In order to critically evaluate frameworks in...

Université de Fribourg

Appropriate uses of EICAT protocol, data and classifications

Kumschick, Sabrina ; Bacher, Sven ; Bertolino, Sandro ; Blackburn, Tim M. ; Evans, Thomas ; Roy, Helen E. ; Smith, Kevin

In: NeoBiota, 2020, vol. 62, p. 193–212

The Environmental Impact Classification for Alien Taxa (EICAT) can be used to classify alien taxa according to the magnitude and type of their environmental impacts. The EICAT protocol, classifications of alien taxa using the protocol (EICAT classification) and the data underpinning classifications (EICAT data) are increasingly used by scientists and practitioners such as governments, NGOs...

Università della Svizzera italiana

The prospect and challenges to the flow of liquid biopsy in Africa

Oluwaseyi Temilola, Dada ; Wium, Martha ; Coulidiati, Tangbadioa Herve ; Adeola, Henry Ademola ; Carbone, Giuseppina Maria ; Catapano, Carlo Vittorio Institute of Oncology Research (IOR), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland ; Zerbini, Luiz Fernando

In: Cells, 2019, vol. 8, no. 8, p. 862

Liquid biopsy technologies have the potential to transform cancer patient management as it others non- invasive diagnosis and real-time monitoring of disease progression and treatment responses. The use of liquid biopsy for non-invasive cancer diagnosis can have pivotal importance for the African continent where access to medical infrastructures is limited, as it eliminates the need for...

Université de Fribourg

Fine manual dexterity assessment after autologous neural cell ecosystem (ANCE) transplantation in a non-human primate model of parkinson’s disease

Borgognon, Simon ; Cottet, Jérôme ; Moret, Véronique ; Chatagny, Pauline ; Carrara, Laura ; Fregosi, Michela ; Bloch, Jocelyne ; Brunet, Jean-François ; Rouiller, Eric M. ; Badoud, Simon

In: Neurorehabilitation and Neural Repair, 2019, vol. 33, no. 7, p. 553–567

Autologous neural cell ecosystem (ANCE) transplantation improves motor recovery in MPTP monkeys. These motor symptoms were assessed using semi-quantitative clinical rating scales, widely used in many studies. However, limitations in terms of sensitivity, combined with relatively subjective assessment of their different items, make inter-study comparisons difficult to achieve. Objective. The...