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CD47 promotes age-associated deterioration in angiogenesis, blood flow and glucose homeostasis

Ghimire, Kedar ; Li, Yao ; Chiba, Takuto ; Julovi, Sohel M. ; Li, Jennifer ; Ross, Mark A. ; Straub, Adam C. ; O’Connell, Philip J. ; Rüegg, Curzio ; Pagano, Patrick J. ; Isenberg, Jeffrey S. ; Rogers, Natasha M.

In: Cells, 2020, vol. 9, no. 7, p. 1695

The aged population is currently at its highest level in human history and is expected to increase further in the coming years. In humans, aging is accompanied by impaired angiogenesis, diminished blood flow and altered metabolism, among others. A cellular mechanism that impinges upon these manifestations of aging can be a suitable target for therapeutic intervention. Here we identify cell...

MAGI1 mediates eNOS activation and NO production in endothelial cells in response to fluid shear stress

Ghimire, Kedar ; Zaric, Jelena ; Alday-Parejo, Begoña ; Seebach, Jochen ; Bousquenaud, Mélanie ; Stalin, Jimmy ; Bieler, Grégory ; Schnittler, Hans-Joachim ; Rüegg, Curzio

In: Cells, 2019, vol. 8, no. 5, p. 388

Fluid shear stress stimulates endothelial nitric oxide synthase (eNOS) activation and nitric oxide (NO) production through multiple kinases, including protein kinase A (PKA), AMP-activated protein kinase (AMPK), AKT and Ca2+/calmodulin-dependent protein kinase II (CaMKII). Membrane-associated guanylate kinase (MAGUK) with inverted domain structure-1 (MAGI1) is an adaptor protein that...

Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development

Winnik, Stephan ; Gaul, Daniel ; Preitner, Frédéric ; Lohmann, Christine ; Weber, Julien ; Miranda, Melroy ; Liu, Yilei ; van Tits, Lambertus ; Mateos, José ; Brokopp, Chad ; Auwerx, Johan ; Thorens, Bernard ; Lüscher, Thomas ; Matter, Christian

In: Basic Research in Cardiology, 2014, vol. 109, no. 1, p. 1-15

In Diversity We Trust: The Positive Effect of Ethnic Diversity on Outgroup Trust

Gundelach, Birte

In: Political Behavior, 2014, vol. 36, no. 1, p. 125-142

Clinical presentation and outcome in a series of 88 patients with the cblC defect

Fischer, Sabine ; Huemer, Martina ; Baumgartner, Matthias ; Deodato, Federica ; Ballhausen, Diana ; Boneh, Avihu ; Burlina, Alberto ; Cerone, Roberto ; Garcia, Paula ; Gökçay, Gülden ; Grünewald, Stephanie ; Häberle, Johannes ; Jaeken, Jaak ; Ketteridge, David ; Lindner, Martin ; Mandel, Hanna ; Martinelli, Diego ; Martins, Esmeralda ; Schwab, Karl ; Gruenert, Sarah ; Schwahn, Bernd ; Sztriha, László ; Tomaske, Maren ; Trefz, Friedrich ; Vilarinho, Laura ; Rosenblatt, David ; Fowler, Brian ; Dionisi-Vici, Carlo

In: Journal of Inherited Metabolic Disease, 2014, vol. 37, no. 5, p. 831-840

Secretome of adipose-derived mesenchymal stem cells promotes skeletal muscle regeneration through synergistic action of extracellular vesicle cargo and soluble proteins

Mitchell, Robert ; Mellows, Ben ; Sheard, Jonathan ; Antonioli, Manuela ; Kretz, Oliver ; Chambers, David ; Zeuner, Marie-Theres ; Tomkins, James E. ; Denecke, Bernd ; Musante, Luca ; Joch, Barbara ; Debacq-Chainiaux, Florence ; Holthofer, Harry ; Ray, Steve ; Huber, Tobias B. ; Dengjel, Jörn ; De Coppi, Paolo ; Widera, Darius ; Patel, Ketan

In: Stem Cell Research & Therapy, 2019, vol. 10, no. 1, p. 116

The mechanisms underpinning the regenerative capabilities of mesenchymal stem cells (MSC) were originally thought to reside in their ability to recognise damaged tissue and to differentiate into specific cell types that would replace defective cells. However, recent work has shown that molecules produced by MSCs (secretome), particularly those packaged in extracellular vesicles (EVs), rather...

Antarctica eye study: a prospective study of the effects of overwintering on ocular parameters and visual function

Stahl, Matthew H. ; Kumar, Alexander ; Lambert, Robert ; Stroud, Michael ; Macleod, David ; Bastawrous, Andrew ; Peto, Tunde ; Burton, Matthew J.

In: BMC Ophthalmology, 2018, vol. 18, no. 1, p. 149

In 2013 five polar explorers attempted to complete the first Trans-Antarctic Winter Traverse (TAWT). This study presents the ophthalmological findings for this group, who overwintered in Antarctica as part of the White Mars Human Science Protocol. Antarctic crews are exposed to extreme cold, chronic hypoxia and altered day-night cycles. Previous studies of Antarctic explorers have focused on...

Endothelial Dysfunction as an Early Sign of Atherosclerosis = Bedeutung der Endotheldysfunktion als Frühzeichen der Atherosklerose

Giannotti, Gianna ; Landmesser, Ulf

In: Herz Kardiovaskuläre Erkrankungen, 2007, vol. 32, no. 7, p. 568-572

Pre-operative tracheostomy does not impact on stomal recurrence and overall survival in patients undergoing primary laryngectomy

Pezier, Thomas ; Nixon, Iain ; Joshi, Anil ; Pang, Leo ; Guerrero-Urbano, Teresa ; Oakley, Richard ; Jeannon, Jean-Pierre ; Simo, Ricard

In: European Archives of Oto-Rhino-Laryngology, 2013, vol. 270, no. 5, p. 1729-1735

Developing Hyperpolarized 13C Spectroscopy and Imaging for Metabolic Studies in the Isolated Perfused Rat Heart

Weiss, Kilian ; Mariotti, Erika ; Hill, Deborah ; Orton, Matthew ; Dunn, Joel ; Medina, Rodolfo ; Southworth, Richard ; Kozerke, Sebastian ; Eykyn, Thomas

In: Applied Magnetic Resonance, 2012, vol. 43, no. 1-2, p. 275-288