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Empirical antibiotic therapy for pneumonia in intensive care units: a multicentre, retrospective analysis of potentially pathogenic microorganisms identified by endotracheal aspirates cultures

Scholte, J. ; Duong, H. ; Linssen, C. ; Van Dessel, H. ; Bergmans, D. ; van der Horst, R. ; Savelkoul, P. ; Roekaerts, P. ; van Mook, W.

In: European Journal of Clinical Microbiology & Infectious Diseases, 2015, vol. 34, no. 11, p. 2295-2305

Ampicillin-resistant Haemophilus influenzae isolates in Geneva: serotype, antimicrobial susceptibility, and β-lactam resistance mechanisms

Cherkaoui, A. ; Diene, S. ; Emonet, S. ; Renzi, G. ; Francois, P. ; Schrenzel, J.

In: European Journal of Clinical Microbiology & Infectious Diseases, 2015, vol. 34, no. 10, p. 1937-1945

In vitro evaluation of dual carbapenem combinations against carbapenemase-producing Enterobacteriaceae

Poirel, Laurent ; Kieffer, Nicolas ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2016, vol. 71, no. 1, p. 156-161

Effect of β-lactamase production and β-lactam instability on MIC testing results for Mycobacterium abscessus

Rominski, Anna ; Schulthess, Bettina ; Müller, Daniel M. ; Keller, Peter M. ; Sander, Peter

In: Journal of Antimicrobial Chemotherapy, 2017, vol. 72, no. 11, p. 3070-3078

Rapid disc diffusion antibiotic susceptibility testing for Pseudomonas aeruginosa, Acinetobacter baumannii and Enterococcus spp

Hombach, Michael ; Jetter, Marion ; Blöchliger, Nicolas ; Kolesnik-Goldmann, Natalia ; Keller, Peter M. ; Böttger, Erik C.

In: Journal of Antimicrobial Chemotherapy, 2018, vol. 73, no. 2, p. 385-391

Rapid detection of carbapenemase-producing Pseudomonas spp. using the NitroSpeed-Carba NP test

Sadek, Mustafa ; Poirel, Laurent ; Nordmann, Patrice

In: Diagnostic Microbiology and Infectious Disease, 2021, vol. 99, no. 3, p. 115280

The NitroSpeed-Carba NP test was used to rapidly detect and discriminate between the different types of carbapenemases (classes A, B, and D) within 30 minutes among a collection of 202 Pseudomonas sp. strains (mostly Pseudomonas aeruginosa). A total of 99 carbapenemase–(including enzymes exhibiting weak carbapenemase activity such as several Guyana Extended-Spectrum (GES)-ß-lactamases) and...

Efficacy of dual carbapenem treatment in a murine sepsis model of infection due to carbapenemase-producing Acinetobacter baumannii

Cebrero-Cangueiro, T. ; Nordmann, Patrice ; Carretero-Ledesma, M. ; Pachón, J. ; Pachón-Ibáñez, M. E.

In: Journal of Antimicrobial Chemotherapy, 2020, p. dkaa487

Objectives: To evaluate the in vivo efficacy of a dual carbapenem combination containing imipenem plus meropenem against carbapenem-resistant Acinetobacter baumannii producing carbapenemases OXA-23 or OXA-58.Methods: An experimental model of peritonitis using C57BL/6J female mice was developed and the minimum lethal doses were calculated for infections due to OXA-23 or OXA-58 producers of A. ...

Cross-border emergence of Escherichia coli producing the carbapenemase NDM-5 in Switzerland and Germany

Chakraborty, Trinad ; Sadek, Mustafa ; Yao, Yancheng ; Imirzalioglu, Can ; Stephan, Roger ; Poirel, Laurent ; Nordmann, Patrice

In: Journal of Clinical Microbiology, 2020, p. -

A series of clinical NDM-5-producing E. coli isolates obtained from two surveillance networks of carbapenem-producing Enterobacterales from 2018-2019, namely Switzerland (NARA) and Germany (SurvCARE), were analyzed. The 33 NDM-5- producing E. coli isolates were highly resistant to β-lactams including the novel ß- lactam/ß-lactamase inhibitor combinations (ceftazidime/avibactam, ...

KPC-50 confers resistance to ceftazidime-avibactam associated with reduced carbapenemase activity

Poirel, Laurent ; Vuillemin, Xavier ; Juhas, Mario ; Masseron, Amandine ; Bechtel-Grosch, Ursina ; Tiziani, Simon ; Mancini, Stefano ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2020, vol. 64, no. 8, p. -

KPC-50 is a KPC-3 variant identified from a Klebsiella pneumoniae clinical isolate recovered in Switzerland in 2019. Compared to KPC-3, KPC-50 shows (i) a three- amino-acid insertion (Glu-Ala-Val) between amino acids 276 and 277, (ii) an increased affinity to ceftazidime, (iii) a decreased sensitivity to avibactam, explaining the ceftazidime-avibactam resistance, and (iv) an association with a...

Epidemiology of carbapenemase-producing Klebsiella pneumoniae in northern Portugal: Predominance of KPC-2 and OXA-48

Lopes, Elizeth ; Saavedra, Maria José ; Costa, Eliana ; Lencastre, Hermíniade ; Poirel, Laurent ; Aires-de-Sousa, Marta

In: Journal of Global Antimicrobial Resistance, 2020, vol. 22, p. 349–353

Objectives: To provide, for the first time, data on the molecular epidemiology of carbapenemase-producing Klebsiella pneumoniae clinical isolates from the northern region of Portugal (Trás-os-Montes and Alto Douro).Methods: A total of 106 carbapenemase-producing K. pneumoniae isolates recovered from clinical samples and rectal swabs between January 2018 and March 2019 were included in this...