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Université de Fribourg

A standard numbering scheme for class c β-lactamases

Mack, Andrew R. ; Barnes, Melissa D. ; Taracila, Magdalena A. ; Hujer, Andrea M. ; Hujer, Kristine M. ; Cabot, Gabriel ; Feldgarden, Michael ; Haft, Daniel H. ; Klimke, William ; Akker, Focco van den ; Vila, Alejandro J. ; Smania, Andrea ; Haider, Shozeb ; Papp-Wallace, Krisztina M. ; Bradford, Patricia A. ; Rossolini, Gian Maria ; Docquier, Jean-Denis ; Frère, Jean-Marie ; Galleni, Moreno ; Hanson, Nancy D. ; Oliver, Antonio ; Plésiatyz, Patrick ; Poirel, Laurent ; Nordmann, Patrice ; Palzkill, Timothy G. ; Jacoby, George A. ; Bush, Karen ; Bonomo, Robert A.

In: Antimicrobial Agents and Chemotherapy, 2020, vol. 64, no. 3, p. -

Unlike for classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) β-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative approach that considers both sequence and structure, preserves traditional numbering of catalytically important residues (Ser64, Lys67, Tyr150, and Lys315),...

Université de Fribourg

Computational network biology: Data, models, and applications

Liu, Chuang ; Ma, Yifang ; Zhao, Jing ; Nussinov, Ruth ; Zhang, Yi-Cheng ; Cheng, Feixiong ; Zhang, Zi-Ke

In: Physics Reports, 2020, vol. 846, p. 1–66

Biological entities are involved in intricate and complex interactions, in which uncovering the biological information from the network concepts are of great significance. Benefiting from the advances of network science and high-throughput biomedical technologies, studying the biological systems from network biology has attracted much attention in recent years, and networks have long been...

Université de Fribourg

Notes on the cheek region of the Late Jurassic theropod dinosaur Allosaurus

Evers, Serjoscha W. ; Foth, Christian ; Rauhut, Oliver W.M.

In: PeerJ, 2020, vol. 8, p. e8493

Allosaurus, from the Late Jurassic of North America and Europe, is a model taxon for Jurassic basal tetanuran theropod dinosaurs. It has achieved an almost iconic status due to its early discovery in the late, 19th century, and due to the abundance of material from the Morrison Formation of the western U.S.A., making Allosaurus one of the best-known theropod taxa. Despite this, various...

Université de Fribourg

Late Jurassic theropod dinosaur bones from the Langenberg Quarry (Lower Saxony, Germany) provide evidence for several theropod lineages in the central European archipelago

Evers, Serjoscha W. ; Wings, Oliver

In: PeerJ, 2020, vol. 8, p. e8437

Marine limestones and marls in the Langenberg Quarry provide unique insights into a Late Jurassic island ecosystem in central Europe. The beds yield a varied assemblage of terrestrial vertebrates including extremely rare bones of theropod from theropod dinosaurs, which we describe here for the first time. All of the theropod bones belong to relatively small individuals but represent a wide...

Université de Fribourg

Does being assigned to a low school track negatively affect psychological adjustment?

Müller, Christoph Michael ; Hofmann, Verena

In: School Effectiveness and School Improvement, 2016, vol. 27, p. 95-115

Previous research suggests that the 1st year in secondary school for some students goes hand in hand with an increase in adjustment difficulties. One factor that might influence this process on an individual, compositional, and institutional level is the academic track a student attends. It was hypothesized that being assigned to a lowqualifying track predicts a stronger increase in...

Université de Fribourg

A non-archaeopterygid avialan theropod from the Late Jurassic of southern Germany

Rauhut, Oliver W. M. ; Tischlinger, Helmut ; Foth, Christian

In: eLife, 2019, vol. 8, p. e43789

The Late Jurassic ‘Solnhofen Limestones’ are famous for their exceptionally preserved fossils, including the urvogel Archaeopteryx, which has played a pivotal role in the discussion of bird origins. Here we describe a new, non-archaeopterygid avialan from the Lower Tithonian Mörnsheim Formation of the Solnhofen Archipelago, Alcmonavis poeschli gen. et sp. nov. Represented by a right...

Université de Fribourg

Rhinocerotidae from the early middle miocene locality Gračanica (Bugojno basin, Bosnia-Herzegovina)

Becker, Damien ; Tissier, Jérémy

In: Palaeobiodiversity and Palaeoenvironments, 2019, p. -

The early middle Miocene (European Land Mammal Zone MN5) locality Gračanica (Bugojno Basin, Bosnia-Herzegovina) has yielded numerous well-preserved dental remains of four Rhinocerotidae species: Brachypotherium brachypus, Lartetotherium sansaniense, Plesiaceratherium balkanicum sp. nov. and Hispanotherium cf. matritense. This rhinocerotid assemblage is typical of the Orleanian European Land ...

Università della Svizzera italiana

Tracking public opinion on social media

Giachanou, Anastasia ; Crestani, Fabio (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2018 ; 2018INFO016.

The increasing popularity of social media has changed the web from a static repository of information into a dynamic forum with continuously changing information. Social media platforms has given the capability to people expressing and sharing their thoughts and opinions on the web in a very simple way. The so-called User Generated Content is a good source of users opinion and mining it can be...