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Université de Fribourg

Arginase‐II promotes melanoma migration and adhesion through enhancing hydrogen peroxide production and STAT3 signaling

Yu, Yi ; Ladeiras, Diogo ; Xiong, Yuyan ; Boligan, Kayluz Frias ; Liang, Xiujie ; Gunten, Stephan ; Hunger, Robert E. ; Ming, Xiu‐Fen ; Yang, Zhihong

In: Journal of Cellular Physiology, 2020, p. jcp.29814

Elevated arginase type II (Arg‐II) associates with higher grade tumors. Its function and underlying molecular mechanisms in melanoma remain elusive. In the present study, we observed a significantly higher frequency of Arg‐II expression in melanoma of patients with metastasis than those without metastasis. Silencing Arg‐II in two human melanoma cell lines slowed down the cell growth,...

Université de Fribourg

Computational network biology: Data, models, and applications

Liu, Chuang ; Ma, Yifang ; Zhao, Jing ; Nussinov, Ruth ; Zhang, Yi-Cheng ; Cheng, Feixiong ; Zhang, Zi-Ke

In: Physics Reports, 2020, vol. 846, p. 1–66

Biological entities are involved in intricate and complex interactions, in which uncovering the biological information from the network concepts are of great significance. Benefiting from the advances of network science and high-throughput biomedical technologies, studying the biological systems from network biology has attracted much attention in recent years, and networks have long been...

Université de Fribourg

Computational socioeconomics

Gao, Jian ; Zhang, Yi-Cheng ; Zhou, Tao

In: Physics Reports, 2019, vol. 817, p. 1–104

Uncovering the structure of socioeconomic systems and timely estimation of socioeconomic status are significant for economic development. The understanding of socioeconomic processes provides foundations to quantify global economic development, to map regional industrial structure, and to infer individual socioeconomic status. In this review, we will make a brief manifesto about a new ...

Université de Fribourg

Hypoxia enhances endothelial intercellular adhesion molecule 1 protein level through upregulation of arginase type II and mitochondrial oxidative stress

Liang, Xiujie ; Arullampalam, Prakash ; Yang, Zhihong ; Ming, Xiu-Fen

In: Frontiers in Physiology, 2019, vol. 10, p. -

Hypoxia plays a crucial role in the pathogenesis of cardiovascular diseases. Mitochondrial enzyme arginase type II (Arg-II) is reported to lead to endothelial dysfunction and enhance the expression of endothelial inflammatory adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). In this study, we investigate the role of Arg-II in...

Université de Fribourg

Social signature identification of dynamical social networks

Li, Ren-De ; Liu, Jian-Guo ; Guo, Qiang ; Zhang, Yi-Cheng

In: Physica A: Statistical Mechanics and its Applications, 2018, vol. 508, p. 213–222

Understanding the social relation of dynamical online social networks (OSNs) is significant for identifying the strong and weak ties. In this paper, we empirically investigate the evolution characteristics of Facebook and Wiki users’ social signature, capturing the distribution of frequency of interactions between different alters over time in ego network. The statistical results show that...

Université de Fribourg

Collective iteration behavior for online social networks

Liu, Jian-Guo ; Li, Ren-De ; Guo, Qiang ; Zhang, Yi-Cheng

In: Physica A: Statistical Mechanics and its Applications, 2018, vol. 499, p. 490–497

Understanding the patterns of collective behavior in online social network (OSNs) is critical to expanding the knowledge of human behavior and tie relationship. In this paper, we investigate a specific pattern called social signature in Facebook and Wiki users’ online communication behaviors, capturing the distribution of frequency of interactions between different alters over time in the...

Consortium of Swiss Academic Libraries

To Think Human out of the Machine Paradigm: Homo Ex Machina

Kohler, Alaric

In: Integrative Psychological and Behavioral Science, 2010, vol. 44, no. 1, p. 39-57

Université de Fribourg

Identifying online user reputation in terms of user preference

Dai, Lu ; Guo, Qiang ; Liu, Xiao-Lu ; Liu, Jian-Guo ; Zhang, Yi-Cheng

In: Physica A: Statistical Mechanics and its Applications, 2018, vol. 494, p. 403–409

Identifying online user reputation is significant for online social systems. In this paper, taking into account the preference physics of online user collective behaviors, we present an improved group-based rating method for ranking online user reputation based on the user preference (PGR). All the ratings given by each specific user are mapped to the same rating criteria. By grouping users...

Université de Fribourg

A dynamical approach to identify vertices centrality in complex networks

Guo, Long ; Zhang, Wen-Yao ; Luo, Zhong-Jie ; Gao, Fu-Juan ; Zhang, Yi-Cheng

In: Physics Letters A, 2017, vol. 381, no. 48, p. 3972–3977

In this paper, we proposed a dynamical approach to assess vertices centrality according to the synchronization process of the Kuramoto model. In our approach, the vertices dynamical centrality is calculated based on the Difference of vertices Synchronization Abilities (DSA), which are different from traditional centrality measurements that are related to the topological properties. Through...