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Université de Fribourg

Estimating the accuracy of the MARTINI model towards the investigation of Peripheral Protein-Membrane Interactions

Sriraksha, Srinivasan ; Valeria, Zoni ; Stefano , Vanni

In: Faraday Discussions, 2020, p. -

Peripheral membrane proteins play a major role in numerous biological processes by transiently associating with cellular membranes, often with extreme membrane specificity. Because of the short-lived nature of these interactions, molecular dynamics (MD) simulations have emerged as an appealing tool to characterize at the structural level the molecular details of the protein-membrane...

Université de Fribourg

Positive humor in couples as interpersonal emotion regulation : A dyadic study in everyday life on the mediating role of psychological intimacy

Horn, Andrea B. ; Samson, Andrea C. ; Debrot, Anik ; Perrez, Mainrad

In: Journal of Social and Personal Relationships, 2019, vol. 36, no. 8, p. 2376-2396

The aim of this study was to investigate daily positive humor in couples as an interpersonal emotion regulation strategy. Associated changes in psychological intimacy were tested as a possible socio- affective pathway of emotion regulation that mediates the effects of couple humor on changes in individual momentary affect. Within a dyadic ambulatory assessment framework, 102 couples...

Université de Fribourg

Rapid detection of carbapenemase-producing Pseudomonas spp. using the NitroSpeed-Carba NP test

Sadek, Mustafa ; Poirel, Laurent ; Nordmann, Patrice

In: Diagnostic Microbiology and Infectious Disease, 2021, vol. 99, no. 3, p. 115280

The NitroSpeed-Carba NP test was used to rapidly detect and discriminate between the different types of carbapenemases (classes A, B, and D) within 30 minutes among a collection of 202 Pseudomonas sp. strains (mostly Pseudomonas aeruginosa). A total of 99 carbapenemase–(including enzymes exhibiting weak carbapenemase activity such as several Guyana Extended-Spectrum (GES)-ß-lactamases) and...

Université de Fribourg

Efficacy of dual carbapenem treatment in a murine sepsis model of infection due to carbapenemase-producing Acinetobacter baumannii

Cebrero-Cangueiro, T. ; Nordmann, Patrice ; Carretero-Ledesma, M. ; Pachón, J. ; Pachón-Ibáñez, M. E.

In: Journal of Antimicrobial Chemotherapy, 2020, p. dkaa487

Objectives: To evaluate the in vivo efficacy of a dual carbapenem combination containing imipenem plus meropenem against carbapenem-resistant Acinetobacter baumannii producing carbapenemases OXA-23 or OXA-58.Methods: An experimental model of peritonitis using C57BL/6J female mice was developed and the minimum lethal doses were calculated for infections due to OXA-23 or OXA-58 producers of A. ...

Université de Fribourg

Cross-border emergence of clonal lineages of ST38 Escherichia coli producing the OXA-48-like carbapenemase OXA-244 in Germany and Switzerland

Falgenhauer, Linda ; Nordmann, Patrice ; Imirzalioglu, Can ; Yao, Yancheng ; Falgenhauer, Jane ; M.Hauri, Anja ; Heinmüller, Petra ; Chakraborty, Trinad

In: International Journal of Antimicrobial Agents, 2020, vol. 56, no. 6, p. 106157

Background: Carbapenemase-producing Gram-negative bacteria cause infections that are difficult to treat and represent a rising threat to healthcare systems worldwide. This study analysed isolates of Escherichia coli (E. coli), a species associated with nosocomial-acquired and community-acquired infections, from hospitals in Germany and Switzerland exhibiting a slight decrease in...