In: Faraday Discussions, 2020, p. -
Peripheral membrane proteins play a major role in numerous biological processes by transiently associating with cellular membranes, often with extreme membrane specificity. Because of the short-lived nature of these interactions, molecular dynamics (MD) simulations have emerged as an appealing tool to characterize at the structural level the molecular details of the protein-membrane...
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In: Sustainable Energy & Fuels, 2020, vol. 4, no. 2, p. 589–599
H2 evolution catalyzed by a heptacoordinate complex under both electro- (1) and photo-chemical (2) conditions is analyzed in detail in order to gain insights into the mechanism of the processes. The complex shows high catalytic activity for hydrogen production in acetonitrile, in the presence of trifluoroacetic acid and triethylammonium tetrafluoroborate as proton sources. Foot-of-the-wave...
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In: CHIMIA International Journal for Chemistry, 2020, vol. 74, no. 9, p. 674–680
Colloidal structures are crucial components in biological systems and provide a vivid and seemingly infinite source of inspiration for the design of functional bio-inspired materials. They form multi-dimensional confinements and shape living matter, and transport and protect bioactive molecules in harsh biological environments such as the stomach. Recently, colloidal nanostructures based on...
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In: Materials Chemistry Frontiers, 2020, vol. 4, no. 9, p. 2791–2796
The second-generation Hoveyda–Grubbs (HG2) catalyst, which has a small initiation to propagation rate ratio (ki/kp) in ring-opening metathesis polymerization (ROMP), was successfully used in a recently developed catalytic living ROMP. This proved that slow-initiating catalysts can enable ROMP in a living fashion to produce polymers with narrow dispersity and controlled molecular weight. The...
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In: Current Opinion in Colloid & Interface Science, 2020, vol. 49, p. 82–93
Fluid-like colloidal structures are key components in nature's own functional materials and important for various applications. For instance, self-assembled structures are formed spontaneously by amphiphilic molecules in solvent, tailored by directional noncovalent intermolecular forces. These structures form the framework of cells defining their geometry and microenvironments for chemical...
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In: Angewandte Chemie International Edition, 2020, vol. 60, no. 2, p. 904-909
Some marine plankton called dinoflagellates emit light in response to the movement of surrounding water, resulting in a phenomenon called milky seas or sea sparkle. The underlying concept, a shear-stress induced permeabilisation of biocatalytic reaction compartments, is transferred to polymer-based nanoreactors. Amphiphilic block copolymers that carry nucleobases in their hydrophobic block...
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In: Organic & Biomolecular Chemistry, 2020, vol. 18, no. 40, p. 8034–8057
Metathesis reactions are one of the most reliable and prevalent ways of creating a C– C bond in synthesis. Photochemical variants exist, and they have proven extremely useful for the construction of complex molecules, from natural products to Möbius rings. A variety of starting materials can undergo photometathesis reactions, including alkenes, alkynes, carbonyls, thiocarbonyls, and...
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In: Biomolecular NMR Assignments, 2020, p. -
Soluble guanylate cyclase (sGC) enzyme is activated by the gaseous signaling agent nitric oxide (NO) and triggers the conversion of GTP (guanosine 5′-triphosphate) to cGMP (cyclic guanylyl monophosphate). It contains the heme binding H-NOX (heme- nitric oxide/oxygen binding) domain which serves as the sensor of NO and it is highly conserved across eukaryotes and bacteria as well. Many...
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In: ACS Sensors, 2020, vol. 5, no. 8, p. 2338–2343
Reactions templated by nucleic acids are currently at the heart of applications in biosensing and drug release. The number of chemical reactions selectively occurring only in the presence of the template, in aqueous solutions, and at room temperature and able to release a chemical moiety is still very limited. Here, we report the use of the p-nitrophenyl carbonate (NPC) as a new reactive...
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In: Nanoscale, 2020, vol. 12, no. 33, p. 17362–17372
Evaluating nanomaterial uptake and association by cells is relevant for in vitro studies related to safe-by-design approaches, nanomedicine or applications in photothermal therapy. However, standard analytical techniques are time-consuming, involve complex sample preparation or include labelling of the investigated sample system with e.g. fluorescent dyes. Here, we explore lock-in...
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