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Université de Fribourg

Mitophagy as a stress response in mammalian cells and in respiring S. cerevisiae

Abeliovich, Hagai ; Dengjel, Jörn

In: Biochemical Society Transactions, 2016, vol. 44, no. 2, p. 541–545

The degradation of malfunctioning or superfluous mitochondria in the lysosome/vacuole is an important housekeeping function in respiring eukaryotic cells. This clearance is thought to occur by a specific form of autophagic degradation called mitophagy, and plays a role in physiological homoeostasis as well as in the progression of late-onset diseases. Although the mechanism of bulk...

Université de Fribourg

Feasibility and initial efficacy of a cognitive-behavioural group programme for managing anger and aggressiveness after traumatic brain injury

Aboulafia-Brakha, T. ; Buschbeck, C. Greber ; Rochat, L. ; Annoni, Jean-Marie

In: Neuropsychological Rehabilitation: An International Journal, 2013, vol. 23, no. 2, p. 216-233

This study assesses the feasibility of a cognitive-behavioural group programme for treating anger and aggressiveness after a traumatic brain injury (TBI). Five feasibility criteria were considered: demand, implementation, practicality, acceptability and initial efficacy. A self-report questionnaire of aggressiveness (AQ-12) was administered before the intervention (T1), one week following the...

Université de Fribourg

Phytotoxic metabolites from Neofusicoccum parvum, a pathogen of Botryosphaeria dieback of grapevine

Abou-Mansour, Eliane ; Débieux, Jean-Luc ; Ramírez-Suero, Montserrat ; Bénard-Gellon, Mélanie ; Magnin-Robert, Maryline ; Spagnolo, Alessandro ; Chong, Julie ; Farine, Sibylle ; Bertsch, Christohpe ; L’Haridon, Floriane ; Serrano, Mario ; Fontaine, Florence ; Rego, Cecilia ; Larignon, Philippe

In: Phytochemistry, 2015, vol. 115, p. 207–215

Liquid chromatography-diode array screening of the organic extract of the cultures of 13 isolates of the fungus Neofusicoccum parvum, the main causal agent of botryosphaeria dieback of grapevine, showed similar metabolites. One strain was selected for further chemical studies and led to the isolation and characterisation of 13 metabolites. Structures were elucidated through spectroscopic...

Haute Ecole d'Ingénierie

Développement et caractérisation d'un réacteur à lit fluidisé pour la culture de cellules animales = Entwicklung und Charakterisierung eines Fliessbettreaktor für die Kultur tierischer Zellen

Accetturo, Alessandro ; Eyer, Kurt (Dir.)

Mémoire de diplôme HES : Haute Ecole d'Ingénierie, 2008.

Objectif: La construction du système de culture cellulaire en lit fluidisé est un des objectifs de ce projet. La détermination de la quantité de cellules grâce à une corrélation avec la consommation d’oxygène est développée. Le but final du travail est d’exécuter une culture en continue et de caractériser les paramètres hydrodynamiques et de culture optimales. Résultats: Les...

Université de Fribourg

Mood effects after deep brain stimulation for Parkinson’s disease: an update

Accolla, Ettore A. ; Pollo, Claudio

In: Frontiers in Neurology, 2019, vol. 10, p. 617

Depression in Parkinson's Disease (PD) is a prevalent and invalidating symptom. Deep brain stimulation (DBS) allows for an improvement of PD motor features, but its effects on mood are difficult to predict. Here, we review the evidence regarding mood effects after DBS of either subthalamic nucleus (STN) or globus pallidus pars interna (GPi). Different influences of multiple factors contribute...

Université de Fribourg

Brain networks modulated by subthalamic nucleus deep brain stimulation

Accolla, Ettore A. ; Ruiz, Maria Herrojo ; Horn, Andreas ; Schneider, Gerd-Helge ; Schmitz-Hübsch, Tanja ; Draganski, Bogdan ; Kühn, Andrea A.

In: Brain, 2016, vol. 139, no. 9, p. 2503–2515

Deep brain stimulation of the subthalamic nucleus is an established treatment for the motor symptoms of Parkinson’s disease. Given the frequent occurrence of stimulation- induced affective and cognitive adverse effects, a better understanding about the role of the subthalamic nucleus in non-motor functions is needed. The main goal of this study is to characterize anatomical circuits...

Université de Fribourg

In vivo nuclear translocation of mineralocorticoid and glucocorticoid receptors in rat kidney: differential effect of corticosteroids along the distal tubule

Ackermann, Daniel ; Gresko, Nikolay ; Carrel, Monique ; Loffing-Cueni, Dominique ; Habermehl, Daniel ; Gomez-Sanchez, Celso ; Rossier, Bernard C. ; Loffing, Johannes

In: American Journal of Physiology - Renal Physiology, 2011, vol. 299, no. 6, p. F1473-F1485

Aldosterone and corticosterone bind to mineralocorticoid (MR) and glucocorticoid receptors (GR), which, upon ligand binding, are thought to translocate to the cell nucleus to act as transcription factors. Mineralocorticoid selectivity is achieved by the 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) that inactivates 11β-hydroxy glucocorticoids. High expression levels of 11β-HSD2...

Université de Fribourg

Marcello Malpighi and the evolution of embryology

Adelmann, Howard Bernhardt

Ithaca : Cornell Univ. Press, 1966

(Cornell Publ. in the History of Science)