In: Disability & Rehabilitation, 2008, vol. 30, no. 14, p. 1063 - 1078
Purpose. To illustrate the conceptualization and development of a research institution from the comprehensive perspective based on the integrative model of functioning provided by the World Health Organization's (WHO) International Classification of Functioning, Disability and Health (ICF). The newly founded research institution Swiss Paraplegic Research which focuses on the comprehensive study...
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In: Surgical Endoscopy, 2008, vol. 22, no. 4, p. 901-906
Background: Nowadays, the laparoscopic approach represents the gold standard for a wide range of various basic and advanced procedures. To reduce the learning curve in advanced laparoscopic surgery, the search for new teaching tools is of utmost importance. Our experiences with a new teaching tool to train advanced laparoscopic procedures are reported. Methods: Hands-on training courses in...
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Thèse de doctorat : Université de Fribourg, 2006.
Research on language acquisition has shown that language development depends on language experience during early childhood. Early acquisition of one as opposed to two languages should therefore influence the development of language capabilities. Various psycholinguistic studies have provided support for this idea. The impact of early second language acquisition on the establishment of the...
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Thèse de doctorat : Université de Fribourg, 2000 ; no 1284.
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Thèse de doctorat : Université de Fribourg, 2003 ; no 1409.
The oncogenic transcription factors E2F and Myc bind to specific DNA sequences at distinct times during the G1 phase of the mammalian cell cycle, and regulate transcription of a plethora of target genes. E2F and Myc associate with TRRAP, a subunit of distinct macromolecular complexes that contain the histone acetyltransferases (HATs) Gcn5/PCAF or Tip60. During the course of my thesis I...
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Thèse de doctorat : Université de Fribourg, 2002 ; Nr. 1396.
To cope with the daily changes in their environment, in organisms, from cyanobacteria to humans, endogenous clocks have evolved that anticipate these changes and synchronize physiology and behavior accordingly. In mammals, the central circadian pacemaker is located in the suprachiasmatic nuclei (SCN) of the hypothalamus. From there subordinated cellular clocks in the peripheral organs are...
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In: International Journal of Obesity, 2004, vol. 28 (Suppl. 4), p. S29-S37
Life is a combustion, but how the major fuel substrates that sustain human life compete and interact with each other for combustion has been at the epicenter of research into the pathogenesis of insulin resistance ever since Randle proposed a 'glucose-fatty acid cycle' in 1963. Since then, several features of a mutual interaction that is characterized by both reciprocality and dependency between...
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Thèse de doctorat : Université de Fribourg, 2001 ; no 1354.
Dans le monde des Eucaryotes inférieurs ou supérieurs, de nombreuses glycoprotéines sont ancrées dans leur membrane plasmique par l’intermediaire d’une ancre GPI (glycosylphosphatidylinositol). Cette modification post-traductionnelle est nécessaire pour la croissance et le développement de la levure Saccharomyces cerevisiae. Chez cet organisme, environ 70 cadres ouverts de lecture...
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Thèse de doctorat : Université de Fribourg, 2000 ; nr. 1321.
L’apoptose (ou mort cellulaire programmée) est un processus cellulaire essentiel présent dans la majorité des organismes. Afin de préserver l’homéostase des tissus, un nombre comparable de cellules doit mourir pour maintenir l'équilibre avec les cellules produites par mitose. Cependant, dans de nombreuses maladies (en particulier le cancer), ce méchanisme de mort cellulaire est...
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Thèse de doctorat : Université de Fribourg, 2000 ; no 1307.
La tenascine-R (TN-R) est une glycoprotéine de la matrice extracellulaire du cerveau (Zamze et al., 1999) dont la distribution est restreinte au système nerveux central. (Pesheva et al., 1989; Rathjen et al., 1991; Weber et al., 1999) Une des caractéristiques de la TN-R et de quelques-uns de ses ligands connus, est son accumulation autour de certaines sous-population de neurones, formant ainsi...
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