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Université de Fribourg

Evaluation of the potential of cobalamin derivatives bearing ru(ii) polypyridyl complexes as photosensitizers for photodynamic therapy

Jakubaszek, Marta ; Rossier, Jeremie ; Karges, Johannes ; Delasoie, Joachim ; Goud, Bruno ; Gasser, Gilles ; Zobi, Fabio

In: Helvetica Chimica Acta, 2019, vol. 102, no. 7, p. -

The current photosensitizers (PSs) for photodynamic therapy (PDT) lack selectivity for cancer cells. To tackle this drawback, in view of selective cancer delivery, we envisioned conjugating two ruthenium polypyridyl complexes to vitamin B12 (Cobalamin, Cbl) to take advantage of the solubility and active uptake of the latter. Ultimately, our results showed that the transcobalamin pathway is...

Université de Fribourg

Antiplasmodial activity and in vivo bio-distribution of chloroquine molecules released with a 4-(4-ethynylphenyl)-triazole moiety from organometallo-cobalamins

Rossier, Jeremie ; Sovari, Sara Nasiri ; Pavic, Aleksandar ; Vojnovic, Sandra ; Stringer, Tameryn ; Bättig, Sarah ; Smith, Gregory S. ; Nikodinovic-Runic, Jasmina ; Zobi, Fabio

In: Molecules, 2019, vol. 24, no. 12, p. 2310

We have explored the possibility of using organometallic derivatives of cobalamin as a scaffold for the delivery of the same antimalarial drug to both erythro- and hepatocytes. This hybrid molecule approach, intended as a possible tool for the development of multi-stage antimalarial agents, pivots on the preparation of azide- functionalized drugs which, after coupling to the vitamin, are...

Public access from May 1, 2020
Université de Neuchâtel

Dispersal limitations and historical factors determine the biogeography of specialized terrestrial protists

Singer, David ; Mitchell, Edward A. D ; Payne, Richard J ; Blandenier, Quentin ; Duckert, Clément ; Fernández, Leonardo D ; Fournier, Bertrand ; Hernández, Cristián E ; Granath, Gustaf ; Rydin, Håkan ; Bragazza, Luca ; Koronatova, Natalia G ; Goia, Irina ; Harris, Lorna I ; Kajukało, Katarzyna ; Kosakyan, Anush ; Lamentowicz, Mariusz ; Kosykh, Natalia P ; Vellak, Kai ; Lara, Enrique

In: Molecular Ecology, 2019, vol. 28, no. 12, p. 3089-3100

Recent studies show that soil eukaryotic diversity is immense and dominated by micro‐organisms. However, it is unclear to what extent the processes that shape the distribution of diversity in plants and animals also apply to micro‐organisms. Major diversification events in multicellular organisms have often been attributed to long‐term climatic and geological processes, but the impact of...

Université de Fribourg

pH-responsive nano-self-assemblies of the anticancer drug 2-hydroxyoleic acid

Prajapati, Rama ; Gontsarik, Mark ; Yaghmur, Anan ; Salentinig, Stefan

In: Langmuir, 2019, vol. 35, no. 24, p. 7954–7961

pH-responsive lipid nanocarriers have the potential to selectively target the acidic extracellular pH environment of cancer tissues and may further improve the efficacy of chemotherapeutics by minimizing their toxic side-effects. Here, we present the design and characterization of pH-sensitive nano-self-assemblies of the poorly water-soluble anticancer drug 2-hydroxyoleic acid (2OHOA) with...

Université de Fribourg

Multifunctional nano‐biointerfaces: cytocompatible antimicrobial nanocarriers from stabilizer‐free cubosomes

Zabara, Mahsa ; Senturk, Berna ; Gontsarik, Mark ; Ren, Qun ; Rottmar, Markus ; Maniura-Weber, Katharina ; Mezzenga, Raffaele ; Bolisetty, Sreenath ; Salentinig, Stefan

In: Advanced Functional Materials, 2019, p. 1904007

The rational design of alternative antimicrobial materials with reduced toxicity toward mammalian cells is highly desired due to the growing occurrence of bacteria resistant to conventional antibiotics. A promising approach is the design of lipid‐based antimicrobial nanocarriers. However, most of the commonly used polymer‐stabilized nanocarriers are cytotoxic. Herein, the design of a...

Université de Fribourg

Reduction of nanoparticle load in cells by mitosis but not exocytosis

Bourquin, Joël ; Septiadi, Dedy ; Vanhecke, Dimitri ; Balog, Sandor ; Steinmetz, Lukas ; Spuch-Calvar, Miguel ; Taladriz-Blanco, Patricia ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: ACS Nano, 2019, vol. 13, no. 7, p. 7759–7770

The long-term fate of biomedically relevant nanoparticles (NPs) at the single cell level after uptake is not fully understood yet. We report that lysosomal exocytosis of NPs is not a mechanism to reduce the particle load. Biopersistent NPs such as nonporous silica and gold remain in cells for a prolonged time. The only reduction of the intracellular NP number is observed via cell division,...

Université de Fribourg

Phase transformation of superparamagnetic iron oxide nanoparticles via thermal annealing: implications for hyperthermia applications

Crippa, Federica ; Rodriguez-Lorenzo, Laura ; Hua, Xiao ; Goris, Bart ; Bals, Sara ; Garitaonandia, José S. ; Balog, Sandor ; Burnand, David ; Hirt, Ann M. ; Haeni, Laetitia ; Lattuada, Marco ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: ACS Applied Nano Materials, 2019, vol. 2, no. 7, p. 4462–4470

Magnetic hyperthermia has the potential to play an important role in cancer therapy and its efficacy relies on the nanomaterials selected. Superparamagnetic iron oxide nanoparticles (SPIONs) are excellent candidates due to the ability of producing enough heat to kill tumor cells by thermal ablation. However, their heating properties depend strongly on crystalline structure and size, which may...

Université de Fribourg

Polymer-coated gold nanospheres do not impair the innate immune function of human b lymphocytes in vitro

Hočevar, Sandra ; Milošević, Ana ; Rodriguez-Lorenzo, Laura ; Ackermann-Hirschi, Liliane ; Mottas, Ines ; Petri-Fink, 6 Alke ; Rothen-Rutishauser, Barbara ; Bourquin, Carole ; Clift, Martin James David

In: ACS Nano, 2019, vol. 13, no. 6, p. 6790–6800

Gold nanoparticles (GNPs) are intended for use within a variety of biomedical applications due to their physicochemical properties. Although, in general, biocompatibility of GNPs with immune cells such as macrophages and dendritic cells is well established, the impact of GNPs on B lymphocyte immune function remains to be determined. Since B lymphocytes play an important role in health and...

Université de Fribourg

Lock‐in thermography to analyze plasmonic nanoparticle dispersions

Steinmetz, Lukas ; Taladriz‐Blanco, Patricia ; Geers, Christoph ; Spuch‐Calvar, Miguel ; Bonmarin, Mathias ; Balog, Sandor ; Rothen‐Rutishauser, Barbara ; Petri‐Fink, Alke

In: Particle & Particle Systems Characterization, 2019, p. 1900224

The physicochemical properties of nanoparticles (NPs) strongly rely on their colloidal stability, and any given dispersion can display remarkably different features, depending on whether it contains single particles or clusters. Thus, developing efficient experimental methods that are able to provide accurate and reproducible measures of the NP properties is a considerable challenge for both...

Université de Fribourg

Synthesis and structural analysis of polynuclear silver(I) complexes with 4,7-phenanthroline

Stanojević, Ivana M. ; Savić, Nada D. ; Crochet, Aurélien ; Fromm, Katharina M. ; Đuran, Miloš I. ; Glišić, Biljana Đ.

In: Journal of the Serbian Chemical Society, 2019, vol. 84, no. 7, p. 689–699

New polynuclear silver(I) complexes, [Ag(CF3SO3)(4,7-phen)(CH3CN)]n (1) and [Ag(PO2F2)(4,7-phen)]n (2), were synthesized by the reaction of 4,7-phenanthroline (4,7-phen) and the corresponding AgX salt (X = CF3SO3 - and PF6 -) in 1:2 mole ratio, respectively, in methanol/acetone (1:1 volume ratio) at room temperature. The characterization of the complexes was established on the basis of...